There is limited evidence for the carcinogenicity of p‐chloro-o-toluidine from epidemiological studies in humans. Three cohort studies found high relative risks for urinary-bladder cancer among workers exposed to p-chloro-o-toluidine; however, confounding by coexposure to other potential urinary-bladder carcinogens could not be ruled out. Documented human exposure to p‐chloro-o-toluidine has oc...

Railway optimization problems have been studied from a mathematical programming perspective for decades. This approach is particularly well suited to model the multitude of constraints that typically arises in the context of a railway system. In recent years, these problems have attracted some attention in the algorithms community, with a focus on individual problem aspects, in an attempt to un...

This paper introduces Open Planning Process Pan els O P These panels are based on explicit mod els of the planning process and are used to coor dinate the development and evaluation of multiple courses of action We describe the generic ideas behind O P technology a general methodology for build ing O P interfaces and two applications based on O P technology the Air Campaign Planning Pro cess Pa...

In the title mol-ecule, C(19)H(25)N(2)O(2)P, the P atom is bonded in a distorted tetra-hedral environment. The dihedral angle between the two phenyl rings is 89.09 (8)°. The methyl H atoms are disordered over two sets of sites with equal occupancy. The O atom of the P=O group acts as a double hydrogen-bond acceptor of the type (N-H)(2)⋯(O=)P-, forming R(2) (2)(8) rings which are further linked ...

two simple visible spectrophotometric methods are developed and validated for the quantification of modafinil using 1,2-naphthoquinone-4-sulphonic acid (nqs method) and 2,4-dinitrophenol (dnp method) as analytical reagents. the nqs method involves the reaction of modafinil with 1,2-naphthoquinone-4-sulphonate in alkaline medium at room conditions to form a yellow colored product exhibiting maxi...

objectives: controversial findings exist regarding the association between neonate gender and umbilical cord blood lipid levels. this study aims to compare the levels of lipids and lipoprotein b-100 in the umbilical cord blood of male and female newborns and assess the impact of these factors on neonatal anthropometric measurements. methods: this cross-sectional study was performed on 75 health...

it is widely thought that bcl-2 family proteins regulate commitment to apoptosis primarily through their capacity to control the permeability of the mitochondrial outer membrane permeabilization (momp) triggers the release of multiple apoptogenic factors into the cytosol and, thereby apoptosis. various bcl-2 family members affect this key event of the apoptotic cascade in different ways, determ...

degradation of o,o-dimethyl -o-4-nitrophenylphosphorothioate (methylparathion) by ozonation in aqueous solution was studied in a batch reactor under constant ozone dosage and variable ph conditions. the effectiveness of the process was estimated based on the degree of cod (chemical oxygen demand) reduction and conversion of methylparathion. it was observed that ozonation is more effective at a...

We now know that approximately 30,000 to 40,000 genes effectively control and regulate the human body. The recent completion of a rough draft of the human genome and the complete sequence of Drosophila melanogaster, Caenorhabditis elegans, Mycobacterium tuberculosis, and numerous other sequencing projects provide a vast amount of genomic data for further refinement and analysis.1 These landmark...