Areca nut is one of the most widely used psychoactive substances with several hundred million users worldwide, predominantly in southern Asia. Areca nut can be chewed alone or in a variety of ways that differ by region. The habit of chewing betel quid, containing fresh, dried or cured areca nut, catechu, slaked lime and flavouring ingredients wrapped in betel leaf, is widespread in India, Pakis...

Three hundred and ninety-three samples of dairy products (124 samples of white cheese, 61 samples of cream cheese, 76 samples of Kashar cheese, and 132 samples of butter), 91 samples of cashew nut and 97 macademia nut marketed in Eastern Province, Saudi Arabia during September 2010-September 2011, were analyzed for aflatoxin M1 (AFM1), total aflatoxin and AFB1 by microtitre plate enzyme linked ...

2002 Winstock A. Areca nut-abuse liability, dependence and public health. Addict Biol 2002; 7:133± 8. Williams S, Malik A, Chowdhury S, Chauhan S. Socio-cultural aspects of areca nut use. Addict Biol 2002;7:147± 54. Warnakulasuriya S. Areca nut use following migration and its consequences. Addict Biol 2002;7:127± 32. Trivedy CR, Craig G, Warnakulasuriya S. The oral health consequences of chewin...

The physicochemical and sensory properties of peanut spreads fortified with soy flour were studied. Peanut spreads were replaced by whole soybean flour and soy nut flour at 0, 5, 15, 20 and 30% (w/w). All samples were analyzed for fat, protein, sugar, moisture content, adhesiveness, cohesiveness, hardness and sensory characteristics. Replacing peanut spread with soy flour had significant effect...

PURPOSE Because the nongenotoxic inhibitor of the p53/MDM2 interactions Nutlin-3 has shown promising in vitro therapeutic activity against a variety of p53(wild-type) cancer cells, in this study we evaluated an innovative strategy able to specifically target Nutlin-3 toward CD20(+) malignant cells. EXPERIMENTAL DESIGN The cytotoxic effects of Nutlin-3 encapsulated into poly(lactide-co-glycoli...

INTRODUCTION Areca nut chewing has been shown to increase the risk of cardiovascular disease, but its association with erectile dysfunction (ED) has not been investigated. AIM To investigate the association between areca nut chewing and risk of ED. METHODS Consecutive men at public health centers for oral malignancy screening or health checkup were invited to complete a questionnaire. MAI...

Purpose: Because the nongenotoxic inhibitor of the p53/MDM2 interactions Nutlin-3 has shown promising in vitro therapeutic activity against a variety of p53 cancer cells, in this study we evaluated an innovative strategy able to specifically target Nutlin-3 toward CD20þ malignant cells. Experimental Design: The cytotoxic effects of Nutlin-3 encapsulated into poly(lactide-co-glycolide) nanoparti...

UNLABELLED NUT midline carcinoma (NMC) is an aggressive subtype of squamous cell carcinoma that typically harbors BRD4/3-NUT fusion oncoproteins that block differentiation and maintain tumor growth. In 20% of cases, NUT is fused to uncharacterized non-BRD gene(s). We established a new patient-derived NMC cell line (1221) and demonstrated that it harbors a novel NSD3-NUT fusion oncogene. We find...

OBJECTIVE To determine the effects of soy consumption on markers of inflammation and endothelial function in postmenopausal women with the metabolic syndrome. RESEARCH DESIGN AND METHODS This randomized cross-over clinical trial included 42 postmenopausal women with the metabolic syndrome. Participants were randomly assigned to consume a control diet (Dietary Approaches to Stop Hypertension [...

Background: Epidemiological studies have consistently associated nut consumption with reduced risk for coronary heart disease. Subsequently, many dietary intervention trials investigated the effects of nut consumption on blood lipid levels. The objectives of this study were to estimate the effects of nut consumption on blood lipid levels and to examine whether different factors modify the effects.