Nucleophosmin (NPM) is a multifunctional nuclear phosphoprotein and a histone chaperone implicated in chromatin organization and transcription control. Oncogenic Kaposi's sarcoma herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). In the infected host cell KSHV displays two modes of infection, the latency and...

Nucleophosmin (NPM) mutations have been found in a significant proportion of adults with de novo acute myeloid leukemia (AML), especially in those of a normal karyotype. These results provide a basis for studies of the pathogenesis in this specific subgroup of AML. In this study, NPM mutations were analyzed in 173 Chinese patients of de novo AML, including adults and children. We found that NPM...

Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is a constitutively active fusion tyrosine kinase involved in lymphomagenesis of human anaplastic large cell lymphomas (ALCL), the maturation and activity of which depend on the association with the heat shock protein (hsp) 90 protein chaperone. Targeting hsp90 by the ansamycins geldanamycin and 17-allyl-amino-demethoxygeldanamycin (17-AAG) pro...

Nonparametric profile monitoring (NPM) is for monitoring over time a functional relationship between a response variable and one or more explanatory variables when the relationship is too complicated to be specified parametrically. It is widely used in industry for the purpose of quality control of a process. Existing NPM approaches require a fundamental assumption that design points within a p...

This study aims to examine and analyze the factors that influence stock price volatility in sub-construction building companies listed on Indonesia Stock Exchange 2015-2020. Determination of sample using purposive sampling method, obtained was 9 2015-2020 period order obtain 54 observational data. The data used are secondary analysis technique is multiple linear regression method by conducting ...

Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades, leading to increased cell growth, resistance to apoptosis, and changes in morphology and migration of ...

This special issue of FAM is about how New Public Management (NPM) ideas will develop in the future. The articles included in this special issue were selected from papers presented at the fifth NPM Seminar at Vrije University Amsterdam, 14 September 2005. The 2005 NPM seminar’s objective was to discuss recent experiences with NPM reforms and to look ahead to the possible future of New Public Ma...

This study examined the effect of Liquidity (Current Ratlo), Solvency (Debt to Asset Activity (Total Turnover), Profitability (Net Proflt Margln), and Investment (Dividend Yield) on Growth in Sub Sector Companles Food Beverages llsted Indonesla Stock Exchange for 2018 - 2021 perlod. The research findings suggest that Current Ratlo, DAR, NPM have a signlficant impact proflt growth ln food bevera...

Nucleophosmin (NPM) (B23) is an essential protein in mouse development and cell growth; however, it has been assigned numerous roles in very diverse cellular processes. Here, we present a unified mechanism for NPM's role in cell growth; NPM directs the nuclear export of both 40S and 60S ribosomal subunits. NPM interacts with rRNA and large and small ribosomal subunit proteins and also colocaliz...

Anaplastic large-cell lymphoma (ALCL) frequently carries the t(2;5)(p23;q35), resulting in aberrant expression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). We show that in 293T and Jurkat cells, forced expression of active NPM-ALK, but not kinase-dead mutant NPM-ALK (210K>R), induced JNK and cJun phosphorylation, and this was linked to a dramatic increase in AP-1 transcriptional activ...