The nucleus pulposus is an aggrecan-rich hydrated tissue that permits the intervertebral disc to resist compressive loads. Adaptation to loading is achieved through an elevation in disc osmolarity mediated by the numerous charged glycosoaminoglycan side chains of the aggrecan molecule. The goal of this investigation was to determine the functional role of the osmo-regulatory protein, TonEBP, in...

Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the ...

It was recently seen that puncture of an intervertebral disc in the rat induced disc hernia-like nodules over the puncture site and that the presence of nucleus pulposus was necessary to produce such nodules. Since TNF from the nucleus pulposus have been found to be involved in pain production the aim was to see if also TNF was involved in the formation of such nodules. Two TNF-inhibitors, infl...

In some lumbar disc herniation patients, noninvasive measures fail, necessitating more aggressive treatment, such as epidural steroid injections or surgery. This study sought to determine whether improvement in patients who receive epidural steroid injections is related to regression of herniated nucleus pulposus or whether such patients' symptoms decrease because of the steroid effect in the p...

This study was undertaken to prove that the selectively infiltrated parts of nucleus pulposus with indigo carmine was degenerated parts of nucleus pulposus. This study was done, between August and October 2002, in 5 patients, who received endoscopic discectomy, due to intervertebral disc herniation. Discogram was done with mixture of indigo carmine and radioactive dye. Blue discolored part was ...

The purpose of this study was to examine the repairing effect of KLD-12 polypeptide/TGF-β1 nanofiber gel combined with BMSCs in a rabbit intervertebral disc degeneration model. The rabbit models were divided into four groups after 2 weeks: KLD-12 polypeptide/TGF-β/BMSCs gel (A), normal saline (B), KLD-12 polypeptide/BMSCs gel (C), and no treatment (D). X-ray examination revealed that the %DHI (...