The dual information-function nature of nucleic acids has been exploited in the laboratory to isolate novel receptors and catalysts from random DNA and RNA sequences by cycles of in vitro selection and amplification. This strategy is particularly effective because, unlike polypeptides with random amino acid sequences, nucleic acids with random base sequences are often capable of stably folding ...

The w3DNA (web 3DNA) server is a user-friendly web-based interface to the 3DNA suite of programs for the analysis, reconstruction, and visualization of three-dimensional (3D) nucleic-acid-containing structures, including their complexes with proteins and other ligands. The server allows the user to determine a wide variety of conformational parameters in a given structure--such as the identitie...

In this study, a single-base change discrimination strategy was developed through enhanced DNA toehold exchange reaction on a chip surface. A DNA strand with single-base change (SNPs, insertion or deletion) at an arbitrary position was clearly discriminated with nucleic acid concentrations from 0.8 nM to 1 μM through this method.

In this communication, we demonstrate for the first time the proof of concept that single-walled carbon nanohorns can be used as an effective fluorescent sensing platform for nucleic acid detection with a high selectivity down to single-base mismatch.

In this communication, we demonstrate for the first time that conducting polymer polyaniline (PANI) nanofibres can serve as a novel fluorescent sensing platform for nucleic acid detection with a high selectivity down to single-base mismatch.

The crystal structure of an 8-mer (S)-GNA duplex is presented. As a tool for phasing, the anomalous diffraction of two copper(II) ions within two artificial metallo-base pairs was employed. The duplex structure confirms a canonical Watson-Crick base pairing scheme of GNA with antiparallel strands. The duplex secondary structure is distinct from canonical A- and B-form nucleic acids and can be d...