نتایج جستجو برای: nora efflux pump

تعداد نتایج: 79438  

2014
Sun Young Cho You Sun Nam Hyung-Seok Yang Yun Soo Soh Min Jin Kim Hee Joo Lee

The efflux pump system has been suggested as an important mechanism in the drug resistance of Mycobacterium tuberculosis (MTB). In this study, molecular analysis of five genes in the efflux pump system of MTB isolates from Korean patients was performed in order to identify appropriate molecular targets. In this study, 35 culture-positive specimens were included. PCR was performed for five efflu...

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Journal: :The Journal of antimicrobial chemotherapy 2011
I Leitner J Nemeth T Feurstein A Abrahim P Matzneller H Lagler T Erker O Langer M Zeitlinger

OBJECTIVES The use of efflux pump inhibitors may be a powerful strategy to overcome transporter-mediated bacterial multidrug resistance. In the present study, we set out to investigate the potency of tariquidar, a third-generation P-glycoprotein inhibitor in clinical development, for overcoming bacterial resistance towards ciprofloxacin. METHODS Staphylococcus aureus 29213 (SA29213) and S. au...

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Journal: مجله دانشگاه علوم پزشکی زنجان 2020
Bahman Mirzaei, Hamid Reza Goli, Lotfollah Davoodi, Mohammad Reza Haghshenas, Parisa Charkhi, Zahra Norouzi Bazgir,

Background and Objective: Efflux pump inhibitors (EPIs) can block efflux pumps and are helpful in potentiating the activity of aminoglycosides against Pseudomonas aeruginosa. The present study compared the effects of phenylalanine-arginine beta naphthylamide (PAβN) and curcumin on aminoglycoside minimum inhibitory concentration (MIC) on Pseudomonas aeruginosa clinical isolates. Materials and M...

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Journal: :Journal of medical microbiology and infectious diseases 2022

The adeH and adeS Efflux Pump Genes in Imipenem Colistin-Resistant Acinetobacter baumannii Clinical Isolates

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ژورنال: Medical Laboratory Journal 2017
Vaez , Hamid , Khademi , Farzad , Vaez , Vahid ,

ABSTRACT            Background and Objectives: Pseudomonas aeruginosa is an important non-fermenting gram-negative hospital-acquired pathogen. Treatment of P. aeruginosa infections has become more challenging due to overexpression of efflux pumps. The aim of the present study was to apply in silico analysis to evaluate the structure of the effl...

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ژورنال: پژوهش در پزشکی 2016
اسلامی, گیتا, سبکبار, آذر, سعادتیان فریور, آرزو, نوروزی, جمیله, هاشمی, علی,

Background: The increasing emergence of antimicrobial resistance among gram negative bacteria especially Enterobacteriaceae has become a global problem. Klebsiella pneumoniae is an opportunistic pathogen, which recently due to causing broad spectrum of disease and antibiotic resistance has been lionized. Efflux pumps are one of the antibiotic resistance mechanisms, which were introduced in t...

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Journal: :ACS Infectious Diseases 2017

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Journal: The Iranian Journal of Pharmaceutical Research 2011
Jamaal Kasaeeian Javaad Behravan, Mitra Hassany Mohammad Hassanzadeh Khayat

The drug pump protein MRP2 is a membrane drug efflux transporter widely distributed in normal and tumor tissues. Its role is thought to be crucial for the disposition of many drugs and their substrates in different tissues. In this study, we aimed to examine the effects of systematic inflammation induced by lipopolysaccharide (LPS) on the expression and function of this transporter in rats. Jug...

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ژورنال: پژوهش در پزشکی 2013
دبیری, حسین, دورقی, معصومه, قلاوند, زهره, گودرزی, حسین,

Abstract Background: Efflux systems are components of the bacterial membrane that play a role in homeostasis of the cell and extrusion of toxic compounds. Efflux pumps of the resistance nodulation cell division (RND) superfamily, confer multidrug resistance to their host when over-expressed. One of the RND efflux systems, is AdeABC which have been characterized for A. baumannii. Another pump be...

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Journal: :FEMS microbiology letters 2004
Sacha Lebel Sylvie Bouttier Thierry Lambert

Antibiotic resistance in C. difficile by efflux has been previously suggested. The genome of C. difficile 630 was screened for sequences encoding putative proteins homologous to NorA from Staphylococcus aureus. Four ORFs homologous to efflux genes were cloned into the pAT79 shuttle vector under the control of transcription and translation signals of Gram-positive bacteria and expressed in Enter...

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