Nontuberculous mycobacteria were identified from 45891 samples of 19553 patients with a prediagnosis of pulmonary tuberculosis between November 2004 and January 2009. Among 10041 (21.9%) culture positive samples, 208 (2.1%) pulmonary samples recovered from 77 individual patients were differentiated as mycobacteria other than tuberculosis (MOTT). Proportion of mycobacteria evaluated as causative...

In tuberculosis, infecting mycobacteria are phagocytosed by macrophages, which then migrate into deeper tissue and recruit additional cells to form the granulomas that eventually contain infection. Mycobacteria are exquisitely adapted macrophage pathogens, and observations in the mouse model of tuberculosis have suggested that mycobacterial growth is not inhibited in macrophages until adaptive ...

One third of the world population carries a latent tuberculosis (TB) infection, which may reactivate leading to active disease. Although TB latency has been known for many years it remains poorly understood. In particular, substances of host origin, which may induce the resuscitation of dormant mycobacteria, have not yet been described. In vitro models of dormant ("non-culturable") cells of Myc...

Iron is essential for nearly all biological events. Siderophores are indispensable for most organisms to obtain iron from iron-limiting milieus. This holds particularly true for pathogens such as the causative agent of tuberculosis - Mycobacterium tuberculosis. The categories of mycobacterial siderophores, their biosynthesis and regulation are summarized here. The siderophore biosynthesis and r...

Conducting routine allergy tests of cattle with a simultaneous sample in TB-prone farms is necessary to confirm the stage epizootic process. The purpose research – explore pathomorphological changes cows upon detection para allergic reactions during diagnostic testing for tuberculosis. diagnosis tuberculosis animals was performed comprehensively using all methods control provided guidelines epi...

Introduction Non-tuberculous mycobacteria (NTM) are slow-growing organisms affecting both immunocompromised and immunocompetent patients. As compared to tuberculosis, they pose formidable challenge in successful management beginning with diagnosis extending through its treatment. Case Report Our case highlights unusual spinal presentation of NTM, intricacies in diagnosis, and successful manag...

BACKGROUND Tuberculosis (TB) incidence data in vaccine target populations, particularly adolescents, are important for designing and powering vaccine clinical trials. Little is known about the incidence of tuberculosis among adolescents in India. The objective of current study is to estimate the incidence of pulmonary tuberculosis (PTB) disease among adolescents attending school in South India ...

Tuberculosis is a major infectious disease that requires prolonged chemotherapy with a combination of four drugs. Here we present data suggesting that treatment of Mycobacterium tuberculosis, the causative agent of tuberculosis, and Mycobacterium smegmatis, a model organism widely used for the screening of antituberculosis agents, with first-line drugs resulted in the generation of substantial ...

Pathogenic mycobacteria must acquire iron in the host in order to multiply and cause disease. To do so, they release abundant quantities of siderophores called exochelins, which have the capacity to scavenge iron from host iron-binding proteins and deliver it to the mycobacteria. In this study, we have characterized the exochelins of Mycobacterium bovis, the causative agent of bovine and occasi...