The variegated picture of tuiberculous infection, both spontaneous in man and experimentally induced in animals, has puzzled students and led to most complicated explanations. Most of the earlier experimental studies were handicapped by the lack of two fundamentals which now appear so essential to a solution. One of these was the primary lack of information on the tubercle bacillus and its viru...

A large mucosal immune system controlled by unique, organ-specific regulations operates alongside and separate from the peripheral or systemic immune system. This local immune system is seen as a major interface between the innate and the specific immune system. We have been interested in the immunopathogenesis of a chronic inflammatory bowel disease (IBD) developing in CD4+ T cell-transplanted...

BACKGROUND Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia with severe growth failure and impaired immunity. Impaired immunity may result in increased mortality. AIMS To follow a cohort of 120 CHH patients for mortality from 1971 to 1995. METHODS The overall and cause specific disease mortality rates in patients with CHH, and the disease mortality rate in 194 pare...

Leaves of Murraya koenigii (Linn.) Spreng. (Curry patta) are reported to possess antidiabetic, antimicrobial, cytotoxic and anti-inflammatory activity. In the present study immunomodulatory potential of aqueous extract of its leaves on specific (humoral and cell mediated) and non specific (macrophage) immunity in mice was investigated. Oral administration of the aqueous extract of leaves at the...

There is an interesting relationship between the HIV virus, the health of the gastrointestinal tract, and AIDS wasting syndrome, involving Tumor Necrosis Factor alpha (TNF alpha), specific and non-specific immunity in the gut, gut permeability, and oxidative stress. It is hypothesized that the progression of HIV to full-blown AIDS may be impacted by maintaining a healthy gut. A therapeutic prot...

background: various responses and different prognosis to specific treatment in different patients from one hand, and importance of ifn-γ producer cells on the other hand impressed us to study tc1. methods: the study was conducted in ghaem medical center and bu-ali research institute, mashhad university of medical sciences, iran from 2001 to 2002. lymphocytes of 36 patients were counted and cult...