Protection against ultra violet radiation-induced DNA-damage in the skin is not only provided by the pigmentary system. The epidermal barrier consisting of stratum corneum keratinocytes, filaggrin and other proteins is an additional component of the UV-shield. Disruption of the epidermal barrier through frequent body cleansing with soaps and cosmetics may increase the risk of non-melanoma skin ...

Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen's disease (BD) and actinic keratosis (AK). A topical or systemic exogenous photosensitiser, results in selective uptake by malignant cells. Protoporphyrin IX (PpIX) is produced then activated by the ...

The epidemic of nonmelanoma skin cancer (NMSC) continues, in part due to aging of the world's population, the frequency of early childhood sunburns, and episodic intense recreational sun exposure as opposed to sun exposure related to outdoor occupations. A nonsurgical approach to selected skin cancers could potentially decrease the expense and morbidity of surgical treatment for NMSC. The incre...

Melanoma, also called malignant melanoma, is a form of skin cancer triggered by an abnormal proliferation the pigment-producing cells, which give its color. Melanoma one diseases, exceptionally and globally dangerous, Skin lesions are considered to be serious disease. Dermoscopy-based early recognition detection procedure fundamental for melanoma treatment. Early using dermoscopy images improve...

Skin cancer is one of the most rapidly increasing cancers among the Swedish population and a significant cause of illness and death. This study aims to estimate the total societal cost of skin cancer in Sweden for 2005, using a prevalence-based cost-of-illness approach. The total cost of skin cancer was estimated at euro 142.4 million (euro 15/inhabitant), of which euro 79.6 million (euro 8/inh...

Treatments such as surgical excision, cryotherapy, topical application of imiquimod cream and 5-fluorouracil cream, and radiotherapy are commonly chosen based on the depth and exten‐ sion of the lesions. Limitations and side-effects of the conventional therapies motivate the development of other techniques. Photodynamic therapy (PDT) is presented as an alternative treatment for basal cell carci...

This chapter proposes a novel hierarchical classification system based on the K-Nearest Neighbors (K-NN) model and its application to nonmelanoma skin lesion classification. Color and texture features are extracted from skin lesion images. The hierarchical structure decomposes the classification task into a set of simpler problems, one at each node of the classification. Feature selection is em...

Malignant melanoma is the most common cancer among women and men aged 25-29 [1]. Unfortunately, the incidence of melanoma far surpasses the rate of any other malignancy in this demographic. Due to the growing trends of tanning and advanced nail art, the incidence of melanoma may increase in the coming years. Less than a quarter of patients examine their own skin on a regular basis [2]. An Austr...

Skin cancer represents a major, and growing, public health problem, and is the most common type of cancer observed in Caucasians [1-3]. The three most common forms of skin cancer are basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma. BCC and SCC are together known as non-melanoma skin cancers (NMSC), and are both derived from keratino‐ cytes whereas melanomas are derived fr...

BACKGROUND Skin cancer has reached epidemic proportions, with more new cases diagnosed annually than the combined incidence of cancers of the breast, prostate, lung, and colon. Estimates show 2 to 3 million new cases of non-melanoma skin cancer (NMSC) every year, and, among women, it is the young (younger than 45 years) who are disproportionately affected. OBJECTIVE This article aims to addre...