The canonical JAK-STAT signaling pathway transmits signals from the cell membrane to the nucleus, to regulate transcription of particular genes involved in development and many other physiological processes. It has been shown in Drosophila that JAK and STAT also function in a non-canonical mode, to regulate heterochromatin. This review discusses the non-canonical functioning of JAK and STAT, an...

Recent studies have provided evidence for non-canonical imprinting effects that are associated with allele-specific expression biases at the tissue level in mice. These imprinting effects have features that are distinct from canonical imprinting effects that involve allele silencing. Here, I discuss some of the evidence for non-canonical imprinting effects in the context of random X-inactivatio...

A non-linear version of the multivariate statistical technique of canonical correlation analysis (CCA) is proposed through the integration of a radial basis function (RBF) network. The advantage of the RBF network is that the solution of linear CCA can be used to train the network and hence the training effort is minimal. Also the canonical variables can be extracted simultaneously. It is shown...

We derive a transformation from the usual ADM metric-extrinsic curvature variables on the phase space of Schwarzschild black holes, to new canonical variables which have the interpretation of Kruskal coordinates. We explicitly show that this transformation is non-singular, even at the horizon. The constraints of the theory simplify in terms of the new canonical variables and are equivalent to t...

Migration of neural crest cells is an elaborate process that requires the delamination of cells from an epithelium and cell movement into an extracellular matrix. In this work, it is shown for the first time that the non-canonical Wnt signalling [planar cell polarity (PCP) or Wnt-Ca2+] pathway controls migration of neural crest cells. By using specific Dsh mutants, we show that the canonical Wn...