Nobiletin (NOB) is a polymethoxylated flavone. It has multiple biologic activities that can modulate oxidative stress in many cancer types. However, there no study the literature examined effects of NOB on levels Metastatic Castration-Resistant Prostate Cancer (MCRPC) yet. Motivated from this gap, we investigated impact and superoxide dismutase (SOD) enzyme MCRPC as preliminary study. For purpo...

The mechanism of intestinal absorption of nobiletin (NBL) was investigated using Caco-2 cells. The uptake of NBL from the apical membranes of Caco-2 cells was rapid and temperature-dependent and the presence of metabolic inhibitors, NaN3 and carbonylcyanide p-trifluoromethoxyphenylhydrazone, did not cause a decrease in NBL uptake. The relationship between the initial uptake of NBL and its conce...

Flavonoids are important polyphenolic secondary metabolites in plant. Citrus reticulata 'Chachi' fruit are rich in flavonoids and are being used as functional antioxidant ingredients for the treatment of atherosclerosis and cancer, etc. A high performance liquid chromatography-photodiode array detection system was used to analyze five flavonoids, namely, naringin, hesperidin, didymin, tangereti...

Normal physiological functions require a robust biological timer called the circadian clock. When clocks are dysregulated, misaligned, or dampened, pathological consequences ensue, leading to chronic diseases and accelerated aging. An emerging research area is the development of clock-targeting compounds that may serve as drug candidates to correct dysregulated rhythms and hence mitigate diseas...

OF THE THESIS ....................................................................................... ii ACKNOWLEGEMENT.................................................................................................. iv TABLE OF CONTENTS ................................................................................................. v LIST OF TABLES ..............................................