N-nitrosodi-n-propylamine is not an industrially or commercially important chemical. It is produced in small, laboratory-scale quantities for research purposes. It is also produced inadvertently during certain manufacturing processes, occurring as an impurity in some dinitroaniline pesticides and during manufacture of some extruded rubber products. Nitrosodi­ n-propylamine could also be present...

CMV infection during pregnancy induces a number of N-nitrosation reactions in red blood cells, which violate process of normal hemoglobin oxygenation. Abnormalities in the L-arginine-NO system cause a decrease in the antioxidant capacity of red blood cells, which is associated with reducing the amount of glutathione reductase, glutathione peroxidase and superoxide dismutase.

The combination of a catalytic amount of Cu(OTf)2 and less than a stoichiometric amount of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under an O2 atmosphere effectively promoted the N-nitrosation of both secondary aromatic/aliphatic amines and tertiary aromatic amines with nitromethane (CH3NO2) leading to the preparation of N-nitrosamine derivatives.