An asymmetric Heck reaction allows desymmetrization of substituted cyclic olefins in high dr and ee. A bisphosphine oxide is uniquely stereoselective for this purpose. Desymmetrization of bicyclic olefins via hydroarylation can also be realized in high ee.

ABSTRACT 2-Deoxy-D-ribose was converted to α/β-mixtures of methyl 3-O-acetyl- and methyl 3-O-benzoyl-2-deoxy-5-(p-toluenesulfonyl)-D-ribofuranosides. These were reacted with boron trichloride to generate ribofuranosyl chlorides, which afforded precursors for tracers to image tumor hypoxia on substitution with salts of 2-nitroimidazole. The anomeric ratio of the nucleosides was delicately influe...

Commercially available 4-nitroimidazole can be transformed in a few simple steps into 4-aminoimidazoyl-5-carboximes, from which the respective purine mono-1-oxides may be synthesized. The N→O functionality in these products significantly changes the electron density in the purine skeleton and consequently, the determination of the Hand C-NMR spectra of these simple compounds is somewhat trouble...

The nitroimidazole group of antibiotics like metronidazole have been reported to cause cerebellar ataxia as a rare side effect. Ornidazole, the newest derivative of this class, has a long half life and is very rarely known to cause cerebellar ataxia. Here, we report a 61-year-old patient who developed ataxia due to ornidazole to highlight an unusual adverse event that improved rapidly after dis...

M e t h o d s Data sources: An existing systematic review was updated. Studies were identified by searching 6 electronic databases {MEDLINE (1966 to 2002), EMBASE/Excerpta Medica (1988 to 2002), CINAHL (1982 to 2002), the Cochrane Controlled Trials Register (2002), and SIGLE}*. Study selection and assessment: Studies of any publication status in any language were selected if they were randomize...

A high prevalence of metronidazole resistance in Helicobacter pylorn is reported in developing countries. This study examined whether migrants referred for diagnostic gastroscopy at a United Kingdom centre (n= 54), had a higher prevalence of metronidazole resistance than subjects born in the United Kingdom attending endoscopy (n=46). Records of nitroimidazole treatment prescribed in the United ...

BACKGROUND Several large clinical trials and meta-analyses have shown about 20% failure to eradicate Helicobacter pylori (H.pylori), necessitating investigations for second-line treatments. The aim of this study was to evaluate the effects of clarithromycin-containing quadruple regimen after nitroimidazole-containing quadruple therapy failure. METHODS Thirty two patients who had failed 10-day H...