Azomycin riboside, a congener of the radiosensitizing agent, misonidazole, sensitized hypoxic V79 hamster lung fibroblast cells to radiation and was cytotoxic to these cells. Radiosensitization effectiveness depended on the conditions of hypoxic cell exposure to azomycin riboside (concentration of the latter, time, and temperature). Cytotoxic and radiosensitizing effects resulting from exposure...

Azomycin riboside, a congener of the radiosensitizing agent, misonidazole, sensitized hypoxic V79 hamster lung fibroblast cells to radiation and was cytotoxic to these cells. Radiosensitization effectiveness depended on the conditions of hypoxic cell exposure to azomycin riboside (concentration of the latter, time, and temperature). Cytotoxic and radiosensitizing effects resulting from exposure...

Mammalian cells express at least two subtypes of equilibrative nucleoside transporters, i.e. ENT1 and ENT2, which can be distinguished functionally by their sensitivity and resistance respectively to inhibition by nitrobenzylthioinosine. The ENT1 transporters exhibit distinctive species differences in their sensitivities to inhibition by dipyridamole, dilazep and draflazine (human>mouse>rat). A...

The Center for Advanced Power Systems (CAPS) at Florida State University (FSU) was recently established to pursue research and education in power engineering. Development and demonstration of superconducting technologies is one of the cornerstones of the CAPS program. Important aspects of the program are the test of superconducting equipment at power levels up to 5 MW, and the creation of a rec...

As technology scales, effects such as NBTI increase their importance. The performance degradation in CMOS circuits caused by NBTI is being studied for many years and several models are available. In this work, an equivalent circuit representing one of these models is presented and evaluated through electrical simulation. The proposed circuit is process independent once the chosen model does not...

Gemcitabine and capecitabine are nucleoside analogues used in chemotherapy strategies for the treatment of breast cancer. We previously demonstrated that deficiency in hENT1, the most abundant and widely distributed plasma membrane nucleoside transporter in human cells, confers high-level resistance to gemcitabine toxicity in vitro, whereas the relationship between hENT1 activity and capecitabi...