The new 2,9-dimethyl-4H-oxazolo[5’,4’:4,5]pyrano[3,2-f]quinolin-4-one was successfully prepared through the three-component iodine-catalyzed reaction of n-butyl vinyl ether with 8-amino-2-methyl-4H-chromeno[3,4-d]oxazol-4-one. latter by reduction 2-methyl-8-nitro-4H-chromeno[3,4-d]oxazol-4-one Pd/C in a hydrogen atmosphere. above nitro compound synthesized condensation N-(4-hydroxy-6-nitro-2-ox...

Reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. Substituted-2-(l-methyl-5-nitro-2-imidazo1yl)-4.- methyl-(or phenyl-) quinolines (14) were prepared through the reaction of 2- acetyl-5-nitro-1-methy...

Since FOX-7 (1, 1-diamino-2, 2-dinitroethylene) is a relatively new energetic material, little is known about its physical and chemical properties. Therefore, first-principles quantum chemical calculations are used to predict the energies of atoms of FOX-7. Under gentle heating (thermolysis) is likely to cause hydrogen transfer between molecules, producing highly reactive chemical species. Conv...

Malaria still remains a life-threatening parasitic disease with universal targets set for control and elimination. This study aimed to evaluate the in vitro antimalarial susceptibility of Plasmodium falciparum isolates berghei selected agents column chromatographic subfractions Glyphaea brevis leaves extract FTIR GCMS SF8. Trager Jensen as well World Health Organisation (WHO) standardised micro...

The multicomponent reaction of 2-nitroacetophenone (or nitroacetone), acetaldehyde diethyl acetal, ?-dicarbonyl compound, and ammonium acetate in an acetic acid solution allowed the acquisition previously undescribed 4-methyl-substituted derivatives 5-nitro-1,4-dihydropyridine satisfactory yields. oxidation obtained resulted corresponding 2,4-dimethyl-5-nitropyridines. In addition, for first ti...

Conventional Suzuki–Miyaura arylations use halogenated compounds as electrophilic coupling partners. Although the catalytic activation of organohalides is well established, these substrates are seldom naturally abundant and questions exist to their metabolic environmental friendliness. Owing existence readily available chemical feedstocks, alcohols highly desirable cross-coupling partners, alth...

The birth control pills (contraceptive) are safe, in some cases the combination of contraceptive pill can increase your risk health. side effects include heart attack, stroke, blood clots, and liver tumors. In very rare cases, they lead to death. health problems were minimal or no recorded while using herbal contraceptives. present investigation was focused on preliminary phytochemical analysis...

Copper (II) phthalocyanine and 2,9,16,23 tetrakis nitro copper (II) phthalocyaninehas been synthesized respectively from phthalonitrile and 4-nitro phthalonitrile under solvent-free condition using two different catalystsovernanodimensionalzeolites. 4-Nitro phthalonitrile synthesized from phthalimide in three steps. The newly prepared compounds have been characterized by IR, UV-Vis, 1</sup...

As a means of determining the risk of absorption of water contaminative phenolic compounds through the skin, the permeat ion of a number of phenols, all on the U.S. Environmental Protection Agency ' s list of priority pollutants, through hairless mouse skin has been studied, using in vitro diffusion cell methods. Experimentally determined permeability coefficients through intact skin and stratu...