OBJECTIVES Young people are often exposed to high music levels which make them more at risk to develop noise-induced symptoms such as hearing loss, hyperacusis, and tinnitus of which the latter is the symptom perceived the most by young adults. Although, subclinical neural damage was demonstrated in animal experiments, the human correlate remains under debate. Controversy exists on the underlyi...

The DE values of corn grain for pigs will differ among corn sources. More accurate prediction of DE may improve diet formulation and reduce diet cost. Corn grain sources ( = 83) were assayed with growing swine (20 kg) in DE experiments with total collection of feces, with 3-wk-old broiler chick in nitrogen-corrected apparent ME (AME) trials and with cecectomized adult roosters in nitrogen-corre...

During the last decade the idea of a negative income tax (NIT) as the centerpiece program in antipoverty policy has faded politically to near extinction. Even if political support were favorable, I doubt that the NIT is currently a practical antipoverty proposal. Having made this admission, however, I hasten to say that I did not come to bury the negative income tax, but rather to suggest that ...

Objective: To determine if, in patients with head lice, spinosad cream rinse is more effective than permethrin. Design: Two identical, multicenter, randomized, evaluator/investigator-blinded, active-controlled trials. Setting: Twelve clinical research centers from the United States. Patients: People older than 6 months with live lice infestation as assessed by an evaluator. Intervention: Cluste...

Interleukin-4 (IL-4) is a multifunctional cytokine that plays a critical role in apoptosis, differentiation and proliferation. The intensity of IL4 response depends upon binding to its receptor, IL-4R. The therapeutic efficiency of interleukins can be increased by generating structural mutants having greater stability. In the present work, attempts were made to increase the stability of human I...

Neoadjuvant immunotherapy (NIT), although currently not a standard of care, is evolving as promising treatment strategy for patients with localized deficient mismatch repair (dMMR) colorectal cancer (CRC). NIT checkpoint inhibitors often utilized outside clinical trial in surgically unfit dMMR CRC. We performed National Cancer Database (NCDB) analysis to evaluate the adoption trend CRC and thei...

1. A soluble reduced Methyl Viologen-dependent assimilatory nitrate reductase from Azotobacter vinelandii strain UW136 grown aerobically on nitrate was purified to homogeneity by the criteria of nitrate reductase activity staining, and coincidence of a Coomassie Blue-staining protein band on polyacrylamide gels run under non-denaturing conditions. The specific activity was 3 mumol of NO2- forme...