Niosomes, as a kind of drug delivery system, is widely used for the topical lipophilic drugs. Optimization niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare optimized niosomal formulation simvastatin (nSIM), member statins, through experiment (Response Surface methodology). Optimized were characterized size, polydispersity index (PDI), entr...

Abstract This study aimed to overcome the poor solubility of pterostilbene (PTS) by developing promising reconstituted proethoniosomes (PENs). The PENs loaded with PTS were fabricated according a 2 3 factorial design Design-Expert® software. prepared ethoniosomes assessed for entrapment efficiency (EE %) and % released after 24 h (Q 24h ). According desirability criteria, ethoniosomal formula (...

Nanotechnology has offered enormous improvement in field of therapeutics by means of designing of nano-carriers that can cross biological barriers and are able to target cellular reservoirs. The aim of the present investigation was to formulate and evaluate Niosomes, a synthetic microscopic non-ionic surfactant vesicles formed on the admixture of a non-ionic surfactant, cholesterol and phosphat...

niosomes are non-ionic surfactant vesicles that have potential applications in the delivery of hydrophilic and hydrophobic drugs. the topical form of n-acetyl glucosamine (nag) recently has been considered in the treatment of hyperpigmentation disorders due to its inhibitory effect on thyrosinase enzymes in melanocytes. to improve nag penetration into the skin we formulated the drug in niosomes...

Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should deliver the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are essentially non-ionic surfactant-based multilamellar or unilamellar ves...