Two previously unreported metabolites of nicotinamide have been discovered as urinary excretion products of rats following intraperitoneal injection of nicotinamide-7-i4C or nicotinic acid-7-W. These compounds have been identified as 6-hydroxynicotinamide and 6-hydroxynicotinic acid by comparison of ultraviolet, infrared, and mass spectra and behavior on chromatography and electrophoresis with ...

The hydroxycarboxylic acid family of receptors (ENSFM00500000271913, nomenclature as agreed by the NC-IUPHAR Subcommittee on Hydroxycarboxylic [36, 12]) respond to organic acids, including endogenous hydroxy carboxylic acids 3-hydroxy butyric and L-lactic acid, well lipid lowering agents nicotinic (niacin), acipimox acifran [53, 60, 65]. These were provisionally described receptors, although sh...

1. Single subcutaneous injections of nicotinic acid lowered the serum free fatty acid and triglyceride concentration in two non-fasting Rhesus monkeys. 2. Injections of nicotinic acid repeated daily for 2 4 weeks led to a substantial fall in serum cholesterol concentration, comparable with that obtained in humans given therapeutic doses of nicotinic acid by mouth. 3. The fall in serum cholester...

In September 1937 Elvehjem et al. discovered that a single dose of 30 nig. of Eastman Kodak Company nicotinic acid improved the appetite and stopped the diarrhoea in a dog suffering from black tongue; since this date many people have treated human pellagrins with nicotinic acid. Results from this form of treatment have been sp successful that nicotinic acid is now established as a specific cure...

The mechanisms for the hypolipidemic action of nicotinic acid were examined in 12 patients with hyperlipidemia. Most patients were studied in the hospital on a metabolic ward. The first month was a control period followed by 1 month on nicotinic acid. During treatment with nicotinic acid, the triglycerides (TG) decreased in total plasma by an average of 52% and in very low density lipoproteins ...

This study examines the effect of nicotinic acid (1 g t.d.s.) on serum Lp(a) concentration in a group of patients with type II hyperlipidaemia selected on the basis of a plasma Lp(a) concentration greater than 30 mg/dl. Reductions in total cholesterol, triglyceride, LDL-cholesterol and Lp(a) were 16.3%, 25.5%, 23.7% and 36.4%, respectively, with an increase in HDL cholesterol of 37.3%. The redu...

Nicotinic acid containing pyridine nucleus having side chain at third position gives the significant effect on toxicity to the insects. Therefore, we have reported the synthesis of some nicotinic acid derivatives and their insecticidal activities. The strategy employed for the synthesis of desired nicotinic acid derivatives involved esterification of nicotinic acid. The methyl nicotinate get de...

Nicotinic acid is an effective agent for elevating HDL cholesterol but is limited by side effects. In order to improve tolerance and lipid levels, we combined low-dose nicotinic acid with bezafibrate. We gave low-dose (mean 435 mg/day) nicotinic acid to 37 patients with low HDL cholesterol, bezafibrate (mean 476 mg/day) to 58 patients with elevated total cholesterol and both agents (mean nicoti...

Almost two decades ago Kodicek (194oa, b) observed that nicotinic acid in maize and other cereals is in a bound form that is rendered free only by hydrolysis with alkali ; he postulated that only a small fraction of the total amount of nicotinic acid in maize is ‘active’ and able to prevent or cure pellagra. Subsequent experiments on dogs with the black-tongue syndrome confirmed the hypothesis ...