Background: China is facing the aggravating disease burden of lymphoma. However, accurate information about lymphoma at national and provincial levels limited. Methods: Following general analytical strategy used in Global Burden Diseases, Injuries, Risk Factors Study 2019, age-, sex- province-specific incidence, mortality prevalence Hodgkin (HL) non-Hodgkin (NHL) were analyzed. Lymphoma was ass...

Non-Hodgkin’s lymphoma (NHL) may involve the gynecological tract, and the ovary is one of the most common anatomic site to be involved. Ovarian involvement by NHL is usually secondary, occurring as a part of systemic disease. Localized, presumably primary, NHL of the ovary is rare [1]. Although, there have been few case series of primary NHL of ovary, only one patient with AIDS-related primary ...

Antinuclear antibodies (ANA) are antibodies that bind to several nuclear antigens. ANA have been reported in cancers, suggesting that they may have a role in the pathogenesis of malignancy [4,5]. Many studies have reported that NHL patients could display ANA antibodies [6,7]. This study assessed serum levels of ANA in NHL patients and examined its association with hematological, clinicopatholog...

BACKGROUND Compromised immunity and chronic inflammation are thought to contribute to the development of non-Hodgkin lymphoma (NHL). Because tocopherols protect cells through antioxidant mechanisms, they may play a role in NHL etiology. METHODS This nested case-control study within the Multiethnic Cohort examined the association of prediagnostic serum tocopherols levels measured in 271 NHL ca...

BACKGROUND Non-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore underto...

Commonly observed in lymphoid neoplasms, deletions of 6q have been correlated with histologic and clinical subsets of non-Hodgkin's lymphoma (NHL). Our recent analysis of loss of heterozygosity of 6q loci in NHL showed two regions of minimal molecular deletion (RMD), an RMD1 at 6q25-27 and an RMD2 at 6q21-23. To establish correlations between these RMDs and regions of minimal cytogenetic deleti...

Monoclonal antibodies are standard therapeutics for several cancers including the anti-CD20 antibody rituximab for B cell non-Hodgkin lymphoma (NHL). Rituximab and other antibodies are not curative and must be combined with cytotoxic chemotherapy for clinical benefit. Here we report the eradication of human NHL solely with a monoclonal antibody therapy combining rituximab with a blocking anti-C...

A series of 520 cases of non-Hodgkin‘s lymphoma (NHL; 374 of B-cell, 130 of T-cell, 5 of non-Blnon-T-cell, and 11 of undetermined phenotype) was analyzed for the presence of Epstein-Barr virus (EBV) using RNA in situ hybridization (RISH). The aims of the study were to assess the frequency of EBV-encoded small nuclear RNAs 1 and 2 (EBER), abundant immediate early RNAs (BHLF), and latent membrane...

Angiogenesis is important in development, maintenance and progression of haematological malignancies. Some clinical observations have indicated that in non-Hodgkin's lymphoma (nHL) tumour microvessel density (MVD) may correlate with tumour staging and outcome. The aim of the study was to examine relationship between MVD as a parameter of tumour angiogenesis measured by expression of CD34 and th...

BACKGROUND Various infectious agents like Ebstein Barr Virus (EBV), HTLV-1 and Helicobacter pylori have known as etiologic factors in different sub-types of lymphoma. Although Hepatitis C virus (HCV) has not only been important for its hepatotropism and hepatitis development, but also in recent years its association with some forms of non- Hodgkin's lymphoma (NHL), especially B cell NHL, has re...