Skeletal muscle atrophy is prevalent in chronic diseases, and microRNAs (miRs) may play a key role in the wasting process. miR-23a was previously shown to inhibit the expression of atrogin-1 and muscle RING-finger protein-1 (MuRF1) in muscle. It also was reported to be regulated by cytoplasmic nuclear factor of activated T cells 3 (NFATc3) in cardiomyocytes. The objective of this study was to d...

PURPOSE Wnt pathways control key biological processes that potentially impact on tumor progression and patient survival. We aimed to evaluate DNA methylation at promoter CpG islands (CGI) of Wnt pathway genes in ovarian tumors at presentation and identify biomarkers of patient progression-free survival (PFS). EXPERIMENTAL DESIGN Epithelial ovarian tumors (screening study n = 120, validation s...

Nuclear factor of activated T-cells (NFAT) and calcineurin are essential regulators of immune cell and mesenchymal cell differentiation. Here we show that elevated intracellular calcium induces chondrogenesis through a calcineurin/NFAT signaling axis that activates bone morphogenetic protein (BMP) expression. The calcium ionophore, ionomycin, induced chondrogenesis through activation of calcine...

Although the five-year survival rate of colorectal cancer (CRC) is significantly high with localized stage (90%), only 38% patients are diagnosed at this stage. Therefore, finding risk factors CRC could prevent disease early Obesity and high-fat diet consumption CRC. In detail, oleic acids (OA) were found to accumulate in adipose tissues obese as well being most common long chain fatty acid die...

The failing heart undergoes a process of pathological electrical remodelling that is characterized by maladaptive alterations in ion channel expression and function. This shift in phenotype manifests as electrical instability which increases the occurrence of arrhythmic sudden death. Indeed, it is estimated that of the 300 000 annual deaths related to heart failure, up to 50% are the result of ...