This paper poses three questions: (1) Does mortality from natural causes spike around Christmas and New Year? (2) If so, does this spike exist for all major disease groups or only specialized groups? (3) If twin holiday spikes exist, need this imply that Christmas and New Year are risk factors for death? To answer these questions, we used all official U.S. death certificates, 1979-2004 (n = 57,...

Radiotherapy is a standard treatment for cancer and is used since a long time as a stand-alone therapy or in combination with surgery and systemic therapies including immunotherapy. Its acts through induction of irreversible DNA damage to which tumor cells are more susceptible because of frequent mutations in DNA repair pathways. Fractioned radiotherapy, given as daily low doses during multiple...

As we head towards the end of term and summer holidays, many you will have had electives or other travel plans cancelled as a result ongoing pandemic (doi:10.1136/bmj.n1577). With hotel quarantine system that is not fit for purpose (https://blogs.bmj.com/bmj/2021/06/04/the-uks-hotel-quarantine-system-is-not-fit-for-purpose/) traffic light risks letting new variants into UK (https://blogs.bmj.co...

We propose an algorithm for modeling scenarios newly diagnosed cases of COVID-19 in the Republic Kazakhstan. The is based on treating incomplete epidemiological data and solving inverse problem reconstructing parameters agent-based model (ABM) using set available data. main tool constructing ABM Covasim open library. In event a drastic change situation (appearance new strain, removal or introdu...