نتایج جستجو برای: neutrophil activation

تعداد نتایج: 463084  

Journal: :Circulation research 2002
Sarah Y Yuan Mack H Wu Elena E Ustinova Mingzhang Guo John H Tinsley Primal De Lanerolle Wenjuan Xu

Neutrophil-induced coronary microvascular leakage represents an important pathophysiological consequence of ischemic and inflammatory heart diseases. The precise mechanism by which neutrophils regulate endothelial barrier function remains to be established. The aim of this study was to examine the microvascular endothelial response to neutrophil activation with a focus on myosin light chain kin...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2014
Licia Totani Antonio Piccoli Giuseppe Dell'Elba Amore Concetta Angelomaria Di Santo Nicola Martelli Lorenzo Federico Zehra Pamuklar Susan S Smyth Virgilio Evangelista

OBJECTIVE Platelet-neutrophil interactions play a key role in cardiovascular disease and inflammatory processes. Src family kinases mediate P-selectin glycoprotein ligand-1-Mac-1 cross talk necessary for firm platelet-neutrophil adhesion. Because Src family kinase activity can be regulated by cAMP-dependent pathways, in this work, we evaluated the role of phosphodiesterases in the signaling eve...

Journal: :The Journal of Experimental Medicine 1995
P J Daffern P H Pfeifer J A Ember T E Hugli

Inflammatory action of the potent chemotaxin C5a has been well characterized on a variety of human cell types, including neutrophils, monocytes, basophils, and eosinophils. The cellular effects of C3a are less well defined. Contradictory reports have been published for C3a activation of neutrophils. Recent reports that C3a activates both basophils and eosinophils prompted us to reinvestigate th...

Journal: :BMC Pharmacology 2002
Randolph Corteling Daniel Wyss Alexandre Trifilieff

BACKGROUND Evidence suggests that both the migration and activation of neutrophils into the airway is of importance in pathological conditions such as pulmonary emphysema. In the present study, we describe in vivo models of lung neutrophil infiltration and activation in mice and hamsters. RESULTS BALB/c and C57BL/6 mice were intranasally treated with lipopolysaccharide (0.3 mg/kg). Twenty-fou...

2017
Pablo Alarcón Carolina Manosalva Ivan Conejeros María D. Carretta Tamara Muñoz-Caro Liliana M. R. Silva Anja Taubert Carlos Hermosilla María A. Hidalgo Rafael A. Burgos

Bovine ruminal acidosis is of economic importance as it contributes to reduced milk and meat production. This phenomenon is mainly attributed to an overload of highly fermentable carbohydrate, resulting in increased d(-) lactic acid levels in serum and plasma. Ruminal acidosis correlates with elevated acute phase proteins in blood, along with neutrophil activation and infiltration into various ...

2017
Luísa M D Magalhães Agostinho Viana Augusto C de Jesus Egler Chiari Lúcia Galvão Juliana A Gomes Kenneth J Gollob Walderez O Dutra

Neutrophils are critical players in the first line of defense against pathogens and in the activation of subsequent cellular responses. We aimed to determine the effects of the interaction of Trypanosoma cruzi with human neutrophils, using isolates of the two major discrete type units (DTUs) associated with Chagas' disease in Latin America (clone Col1.7G2 and Y strain, DTU I and II, respectivel...

2013
Patrick Mallia Simon D Message Marco Contoli Katrina K Gray Aurica Telcian Vasile Laza-Stanca Alberto Papi Luminita A Stanciu Sarah Elkin Onn M Kon Malcolm Johnson Sebastian L Johnston

BACKGROUND COPD exacerbations are associated with neutrophilic airway inflammation. Adhesion molecules on the surface of neutrophils may play a key role in their movement from blood to the airways. We analysed adhesion molecule expression on blood and sputum neutrophils from COPD subjects and non-obstructed smokers during experimental rhinovirus infections. METHODS Blood and sputum were colle...

Journal: :Blood 2010
Hoainam Nguyen-Jackson Athanasia D Panopoulos Huiyuan Zhang Haiyan S Li Stephanie S Watowich

Neutrophil mobilization, the release of neutrophils from the bone marrow reserve into circulating blood, is important to increase peripheral neutrophil amounts during bacterial infections. Granulocyte colony-stimulating factor (G-CSF) and chemokines, such as macrophage-inflammatory protein-2 (MIP-2; CXCL2), can induce neutrophil mobilization, but the mechanism(s) they use remain unclear. Signal...

2010
Hoainam Nguyen-Jackson Athanasia D. Panopoulos Huiyuan Zhang Haiyan S. Li Stephanie S. Watowich

Neutrophil mobilization, the release of neutrophils from the bone marrow reserve into circulating blood, is important to increase peripheral neutrophil amounts during bacterial infections. Granulocyte colony-stimulating factor (G-CSF) and chemokines, such as macrophageinflammatory protein-2 (MIP-2; CXCL2), can induce neutrophil mobilization, but the mechanism(s) they use remain unclear. Signal ...

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