Abstract Neutropenia is the most common hematological toxicity of concurrent chemoradiotherapy (CCRT), and leads to subsequent treatment delays and/or dose reductions. often advances febrile neutropenia serious infections, which can affect prognosis safety patients. The reasonable prevention management vital for patients with malignancies undergoing CCRT. Pegylated recombinant human granulocyte...

Human cyclic neutropenia shows many features in common with the animal model of cyclic neutropenia in grey collie dogs. Until now, however, evidence was lacking that cyclic neutropenia in man as in the dog is caused by a defect in a transplantable hematopoietic stem cell. A patient is presented who, while undergoing bone marrow transplantation as treatment for acute lymphoblastic leukemia in re...

We report an extremely rare and complex case of a 44-year-old woman diagnosed with an early stage triple negative breast cancer in the setting of primary autoimmune neutropenia with a pre-existing severe neutropenia. This case-report demonstrates that adjuvant chemotherapy for breast cancer can be administered in a patient with severe neutropenia. The management is however complicated and requi...

Neutropenia encompasses a family of neutropenic disorders, both permanent and intermittent, ranging from severe (<500 neutrophils/mm(3)) to mild (500-1500 neutrophils/mm(3)), which may also affect other organ systems such as the pancreas, central nervous system, heart, muscle and skin. Neutropenia can lead to life-threatening pyogenic infections whose severity is roughly inversely proportional ...

The chemotherapy-induced neutropenia causes mortality and morbidity at a significant rate (Aapro et al., 2011; Fontanella et al., 2014). Fever is frequently observed during chemotherapy-induced neutropenia. Neutropenia-related fever could be encountered for at least once in 10-50% of patients with solid tumor and >80% of patients with hematological malignancy (Freifeld et al., 2011). In patient...

taking clopidogrel in CAPRIE from the neutropenia seen in .1% of patients treated with ticlopidine for greater than 1 month in whom profound life-threatening neutropenia develops requiring cessation of the drug and often requiring therapeutic interventions. This sort of severe neutropenia did not occur in any of the more than 9,000 patients in CAPRIE treated with clopidogrel and has been report...

drug utilization evaluation (due) studies facilitate assessing the appropriateness and rational use of medications.the goal of the present study was to evaluate amphotericin b usage in neutropenic patients. a prospective due study was performed in hematology-oncology and stem cell transplantation wards at taleghani hospital for one-year. national comprehensive cancer network, clinical practice ...

BACKGROUND To compare vancomycin pharmacokinetic parameters in patients with and without neutropenia. METHODS Patients ≥18 years admitted on general wards were included. Routinely vancomycin trough and peak plasma concentrations were measured with a fluorescence polarization immunoassay. Pharmacokinetic parameters of individual patients were determined with maximum a posterior Bayesian estima...