Approximately 30-50% of patients with brain tumors present with seizures as the initial symptom. Seizures play a very important role in the quality of life, particularly in patients with slow-growing primary brain tumors. Tumor-related seizures are often refractory to antiepileptic treatment. Despite the importance of this subject to the fields of neurology, neurosurgery and neurooncology, the ...

Abstract The efficacy of novel targeted therapies is often tested at the time of tumor recurrence. However, for glioblastoma (GBM) patients, surgical resections at recurrence are performed only in a minority of patients; therefore, molecular data are predominantly derived from the initial tumor. Molecular data of the initial tumor for patient selection into personalized medicine trials can ther...

Given the trust the public places in the medical profession, the question of when it might be acceptable to minimally deceive patients, in their best interests, is a challenging one to answer. In this study, we explore neurooncology patients’ attitudes towards dilemmas in which they may feel deceived, and with that information make recommendations on what steps physicians can take to avoid brea...

Primary brain tumors account for less than 2% of all cancers in adults; however, they are often associated with neurologic morbidity and high mortality. Glioblastoma multiforme (GBM) has been a focus of new therapy development in neurooncology because it is the most common primary brain tumor in adults. Standard-of-care therapy for newly diagnosed GBM includes surgical resection, radiotherapy, ...

The treatment of malignant gliomas with current therapies remains a challenge in neurooncology. Our recent work showed that embryonic stem cell (ESC)-derived astrocytes conditionally expressing genes can be used to induce apoptosis in malignant glioma cells in vitro. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene has been shown to induce apoptosis in a variety of tumor...

Glioblastomas are characterized by an intense local invasiveness that limits surgical resection. One mechanism by which glioma cells enforce their migration into brain tissue is reorganization of tumour associated extracellular matrix (ECM). Collagen XVI is a minor component of connective tissues. However, in glioblastoma tissue it is dramatically upregulated compared to the ECM of normal corte...

We present a case of a patient with a radiological diagnosis of gliomatosis cerebri whose clinical presentation mimicked that of viral encephalitis. A 69-year-old female presented with a few days history of confusion, headache and fever. Examination revealed mild extensor weakness in the left upper and lower limb. CSF showed a mild pleocytosis; gram stain, bacterial and viral cultures as well a...

BACKGROUND/AIM At the moment there are few scoring systems for malignant astrocytoma but they are not widely accepted. The aim of this study was to evaluate malignant astrocytoma score (MAS) on a new group of patients with malignant astrocytoma, to compare MAS with other prognostic tools and to describe the use of MAS in everyday practice in neurooncology. METHODS The study was performed on 1...

Medical history, disease onset, clinical symptoms, and results of neuroimaging 14 glossopharyngeal schwannoma patients, who were exa­mined treated in the Subtentorial Neurooncology Department State Institution, Romodanov Institute Neurosurgery NAMS Ukraine (8 patients) No. 2 Municipal Enterprise, Mechnikov Dnipropetrovsk Regional Clinical Hospital Council (6 2018 to 2021 have been analyzed deta...

(1) Background: Fluorescein sodium (Na-Fl) has been described as a safe and useful neurosurgical adjunct in adult neurooncology. However, its use yet to be fully established children. We designed study investigate the of intraoperative Na-Fl pediatric brain tumor surgery. (2) Methods: This is single-institution for patients managed by Neurosurgical Service, KK Women’s Children’s Hospital. Inclu...