Understanding how the brain learns to compute functions reliably, efficiently, and robustly with noisy spiking activity is a fundamental challenge in neuroscience. Most sensory and motor tasks can be described as dynamical systems and could presumably be learned by adjusting connection weights in a recurrent biological neural network. However, this is greatly complicated by the credit assignmen...

Bursting neurons are considered to be a potential cause of over-excitability and seizure susceptibility. The functional influence of these neurons in extended epileptic networks is still poorly understood. There is mounting evidence that the dynamics of neuronal networks is influenced not only by neuronal and synaptic properties but also by network topology. We investigate numerically the influ...

seizure may occur after mild traumatic brain injury (tbi), and the severity of tbi can be considered the most crucial factor for an increased risk of recurring seizures as well as for the development of posttraumatic epilepsy. however, the effect of seizures in epileptogenesis after mild tbi cannot yet be accurately confirmed. this study was designed to determine whether mild tbi increases seiz...

introduction: since organophosphorus compounds (op) are toxic and designed to destroy insects and pest species, there are many hazards associated with their use. although, the main target site of these compounds is acetylcholinesterase (ache), however it has become increasingly evident that ops have also other direct effects on cellular processes. in the present study, the effects of low concen...

This review considers modern data on the morphology and functions of mitochondria in neurons glial cells various brain structures laboratory rodents. We discuss main aspects intracellular regional heterogeneity neuronal mitochondria. The functional differences between different cerebral regions are highlighted. analyze structural features gliocytes as well their role maintaining glioneuronal in...

Simple motor behaviors such as locomotion and respiration involve rhythmic and coordinated muscle movements that are generated by central pattern generator (CPG) networks in the spinal cord and hindbrain. These CPG networks produce measurable behavioral outputs and thus represent ideal model systems for studying the operational principles that the nervous system uses to produce specific behavio...

In this paper we study the effect of noise on HH Model. Small-world, regular and random neural networks are the types of HH neuronal networks, which we study in spiking synchronization. External noise and Sub threshold stimulus are subjected to all the neurons. In neuronal membranes we study biophysically realistic HH neurons with intensity of intrinsic noise via voltage gated ion channels. The...