objective(s) high blood glucose induces molecular, cellular, morphological and behavioral changes in the brain. metabolic disturbances, contribute to the hippocampus injury and development of partial focal seizures. the aim of this study was to investigate the effects of infantile repeated hyperglycemia on neuronal density of hippocampal ca3region in newborn wistar male rats and its effect on c...

Background: Morin hydrate (MH) is a bioflavonoid component of many fruits and vegetables. Our previous investigations demonstrated that MH confer neuroprotection in mouse models of acute restraint stress and sleep deprivation by attenuating hippocampal neuronal damage and enhancing memory. Based on these findings, our study investigated the role of MH in chronic stress-induced neuronal and bioc...

Abstract Background Elevated levels of S-100B in serum are increasingly considered a potential biochemical marker nervous system damage. To our knowledge, limited number research studies have tested the protein children with epilepsy. The objective study is to measure pediatric cases Results mean concentration was 0.135 ± 0.014 mg/L patient group and 0.082 0.018 control group. patients showed s...

Neuropsychiatric disorders are one of the leading causes of disability worldwide and affect the health of billions of people. Previous publications have demonstrated that neuropsychiatric disorders can cause histomorphological damage in particular regions of the brain. By using a clinical symptom-comparing approach, 55 neuropsychiatric signs or symptoms related usually to 14 types of acute and ...

Emerging evidence indicates that D-serine rather than glycine serves as an endogenous agonist at glycine site of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors, in several nervous tissues, including the developing cerebellum and the retina. Here, we examined whether endogenous D-serine plays a significant role in neuronal damage resulting from excitotoxic insults in the cerebral...

Stress has long been known to be a causative factor of various disease states. In this study, we investigated the effects of repeated restraint stress on platelet endothelial cell adhesion molecule-1 (PECAM-1), a very important mediator in inflammation, immunoreactivity and protein levels as well as neuronal damage, in the gerbil hippocampus after 5 minutes of transient cerebral ischemia. Trans...