l,rAzobis[3-methyl-2-phenyl-lH-imidazo(l,2-a)pyridinium] dibromide, AH 8165, produced a competitive neuromuscular block in the mouse, chick, cat, dog and monkey. The paralysis was characterized by a very rapid onset of action and, in all species except the monkey, by a short duration of action comparable to that of suxamethonium. In the monkey, the effect of AH 8165 was more persistent but was ...

Myasthenia gravis is a neuromuscular disease with multisystemic involvement and multiple drug interactions not restricted to blockers, but also including anaesthetic analgesic agents, increasing the risk of anaesthesia-related complications. In this case report, we describe our safe effective technique for Gravis patient submitted Video-Assisted Thoracoscopy thymectomy, requiring block. Since a...

conclusions the results of this study showed that remifentanil, similar to alfentanil, provided excellent conditions for endotracheal intubation when used with propofol for the induction of anesthesia; however, remifentanil improved the patency of the vocal cords to a greater extent than alfentanil. results there were no demographic data differences between groups (age, weight, and sex). furthe...

neostigmine), reverses neuromuscular blockade rapidly and effectively by encapsulating free circulating steroidal neuromuscular blocking agents (e.g., rocuronium) directly [1]. Moreover, sugammadex does not have muscarinic properties, whereas neostigmine has significant adverse muscarinic effects. Therefore, sugammadex is used in many countries as a new neuromuscular reversal agent to antagoniz...

CC This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Anesthesiologists daily use a range of drugs, including intravenous anesthetics, neuro...

The influence of bile salts on the duration of action of the steroidal non-depolarizing neuromuscular blocking agent ORG 6368 was investigated in cats. The intravenous administration of ORG 6368 (100 microgram/kg body wt) caused a maximum neuromuscular blockade of 71 +/- 6% with a duration of action of 3.4 +/- 0.1 min. However, intraportal administration of the same dose caused no significant n...

Although neuromuscular blocking agents (NMBAs) provide optimal surgical conditions and a reduced incidence of laryngopharyngeal lesions during tracheal intubation, there are evidence of delayed paralysis and higher morbidity and mortality after their use. To date many anesthesiologists do not routinely use objective method to monitor neuromuscular function due to the fact that there are no idea...

One of the challenges during the perioperative care of patients with myotonic dystrophy is the reversal of neuromuscular blocking agents. Agents that inhibit acetylcholinesterase, such as neostigmine, may precipitate myotonia, and are therefore relatively contraindicated. Sugammadex is a novel pharmacologic agent, which encapsulates rocuronium or vecuronium, thereby reversing their effect. We r...