Primitive neuroectodermal tumor (PNET) is highly malignant and extremely rare in the spine. We present a case with primary spinal primitive neuroectodermal tumor (PSPNET) which involved epidural space of thoracic spine with cord compression. Magnetic resonance imaging (MRI) showed an isointense epidural lesion on T1WI and T2WI. Heterogeneous enhancement following the administration of gadoliniu...

A neoplastic mass compressing the left cerebellar hemisphere and hindbrain was observed at trimming in a 3½-year-old male cynomolgus monkey from a control dose group. Microscopically, the neoplastic mass was nonencapsulated, invasive, and showed two morphological patterns. The predominant area consisted of densely packed undifferentiated, polygonal to spindle cells arranged in vague shee...

OBJECTIVE To report two new cases of Ewing's sarcoma/primitive neuroectodermal tumor of the kidney, one of them with tumor thrombus in cava. METHOD Characterization of two new cases and literature review by PubMed search. RESULTS We report the cases of two men diagnosed with primary renal Ewing's sarcoma, who have been treated with nephrectomy and adjuvant chemotherapy, being in complete ...

OBJECTIVE To report a hypertensive and systematically pigmented female with primitive neuroectodermal tumors. CLINICAL PRESENTATION AND INTERVENTION A female patient presented with a complaint of right flank pain. She had a right renal space-occupying lesion, underwent right radical nephrectomy, and returned to normotensive postoperatively. The pathological examination identified typical prim...

UNLABELLED The primitive neuroectodermal tumor (PNET) belongs to a group of highly malignant tumors and is composed of small round cells of a neuroectodermal origin. Categorized in the same tumor family as Ewing sarcoma, the PNET is most likely to occur in bones and soft tissues. However, a small number of PNET cases arising in the pelvis have been reported as well. WE PRESENT THREE CASES OF ...

Pineoblastomas are rare, malignant pineal parenchymal tumors encountered predominantly in pediatric patients. They distinct from primitive neuroectodermal (PNET) at other sites that they exhibit photosensory differentiation including Flexner–Wintersteiner rosettes and fleu-rettes. Diagnosis can be challenging since share morphologic immunohistochemical fea-tures with embryonal the developing gl...

Here we report that aloe-emodin (AE), a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor activity. The growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. The compound does not inhibit the proliferation of normal fibroblasts nor that ...

Comparative genomic in situ hybridization analysis of four cell lines derived from SV40 large T antigen-induced primitive neuroectodermal tumors of the rat revealed non-recurrent chromosomal copy number changes and DNA amplifications at chromosomal bands 2q34, 4q43qter and 15q12qter in cell lines TZ102, TZ103 and TZ107, respectively. Semi-quantitative PCR and western blot analysis demonstrated ...

BACKGROUND Congenital brain tumors are very rare. We review these tumors in patients younger than 2 months diagnosed in our Department. METHODS Seven congenital brain tumors were diagnosed during 5 years. Clinical and radiological findings and prognosis were analyzed. RESULTS The study included 5 female and two male infants. Two cases were diagnosed antenatally by means of ultrasonography. ...