نتایج جستجو برای: neuraminidase

تعداد نتایج: 5883  

Journal: :Cell host & microbe 2017
Masaki Imai Tokiko Watanabe Maki Kiso Noriko Nakajima Seiya Yamayoshi Kiyoko Iwatsuki-Horimoto Masato Hatta Shinya Yamada Mutsumi Ito Yuko Sakai-Tagawa Masayuki Shirakura Emi Takashita Seiichiro Fujisaki Ryan McBride Andrew J Thompson Kenta Takahashi Tadashi Maemura Hiromichi Mitake Shiho Chiba Gongxun Zhong Shufang Fan Kohei Oishi Atsuhiro Yasuhara Kosuke Takada Tomomi Nakao Satoshi Fukuyama Makoto Yamashita Tiago J S Lopes Gabriele Neumann Takato Odagiri Shinji Watanabe Yuelong Shu James C Paulson Hideki Hasegawa Yoshihiro Kawaoka

Low pathogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire efficient human-to-human transmissibility. We compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants that represent neuraminidase inhibitor-sensitive and -resistant subpopulations detected within th...

2017
Madhusudan Rajendran Raffael Nachbagauer Megan E Ermler Paul Bunduc Fatima Amanat Ruvim Izikson Manon Cox Peter Palese Maryna Eichelberger Florian Krammer

Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity to a panel of N1, N2, and influenza B virus neuraminidases in different age groups, including children, adults, and the elderly. Using enzyme-...

Journal: :Hiroshima journal of medical sciences 1984
K Kiyotani N Takei Y Matsuo

The fluorometric neuraminidase assay method using 4-methylumbelliferyl-N-Ac-aD-neuraminide as a substrate was investigated for the purpose of ascertaining its validity as a procedure for influenza viral neuraminidase antibody inhibition test. The enzyme antibody inhibition titer obtained by the fluorometric assay system was far weaker than that obtained by the standard colorimetric neuraminidas...

Journal: :Infection and immunity 1974
H E Müller

The enzyme neuraminidase (EC 3.2.1.18) was found to be strongly active in different types of Streptococcus sanguis and S. viridans, and, in addition, the occurrence of the enzyme acylneuraminate pyruvate lyase (EC 4.1.3.3) was described in S. viridans. The enzyme-active bacteria strains were isolated from blood cultures of patients with septicemia. Whereas S. sanguis lost its strong neuraminida...

Journal: :Expert review of pharmacoeconomics & outcomes research 2003
Michaël Schwarzinger Karine Lacombe Fabrice Carrat

Up to 10% of individuals present influenza-like illness each year. Neuraminidase inhibitors significantly reduce the median duration of influenza symptoms by 1.38 days and median time to return to normal activities by 0.9 days in adults. This review presents the economic evaluations of neuraminidase inhibitors in adults. The choice of key parameter estimates in cost-effectiveness and cost-benef...

Journal: :Journal of Medical Microbiology 1981

Journal: :Emerging Infectious Diseases 2018

Journal: :Journal of virology 1972
D J Bucher E D Kilbourne

Neuraminidase activity of influenza virus was directly seen on sodium dodecyl sulfate polyacrylamide gels with the aid of the synthetic substrate, methoxyphenol neuraminic acid. Neuraminidase (NA) appeared as a high-molecular-weight fraction with a size in the range of 220,000 to 250,000 daltons. Isolation of this fraction from the X-7 strain of influenza virus, dissociation with sodium dodecyl...

2012
Shih-Jen Lu Fok-Ching Chong

Control of flavonoid derivatives inhibitors release through the inhibition of neuraminidase has been identified as a potential target for the treatment of H1N1 influenza disease. We have employed molecular dynamics simulation techniques to optimize the 2009 H1N1 influenza neuraminidase X-ray crystal structure. Molecular docking of the compounds revealed the possible binding mode. Our molecular ...

Journal: :Clinical chemistry 2014
Nicholas E Heger Mark D Kellogg

Serum contains 1-transferrin, and CSF contains 1 and 2 transferrins. The 2-transferrin in CSF is desialylated because of the presence of neuraminidase in the central nervous system. Hence, 2-transferrin is used as a marker of CSF leakage (1 ). Because 1-transferrin was present in serum but absent in drainage fluid, additional neuraminidase activity was suspected. This suspicion was supported by...

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