Nonlinear energy sink (NES) refers to a typical passive vibration device connected linear or weakly nonlinear structures for absorption and mitigation. This study investigates the dynamics of 1-dof 2-dof NES with damping combined stiffness oscillator. For system NES, truncation failure frequency are revealed through bifurcation analysis using complex variable averaging method. The detuning inte...

The regulatory peptide ghrelin has been proposed to help mediate both hunger and sleep. The neuroendocrine circadian patterns in the night eating syndrome (NES) have been distinguished by an attenuated nocturnal rise in the plasma concentrations of melatonin and leptin and a greater increase in the concentrations of cortisol. In this study we wanted to test the hypothesis that night eaters have...

The determination of protein assembly size and relative molecular mass is currently of great importance in biochemical analysis. In particular, the technique of nanoelectrospray (nES) with a gas-phase electrophoretic mobility molecular analyzer (GEMMA) has received increased attention for such measurements. However, in order for the GEMMA technique to gain broader acceptance in protein analysis...

Studies revealed that English as a second language (ESL) speakers and native (NES) often used different strategies to offer advice in English. Since these differences can cause cross-cultural misunderstandings misattribution of intent between ESL NES, it is important identify them. For this purpose, study analyzed the structural pragmatic advice-giving NES Turkish speakers. 18 20 students were ...

Transverse galloping is a type of flow-induced vibration (FIV) that leads to critical design considerations for engineering structures. A purely nonlinear energy sink (NES) composed ball free rotate in circular track experimentally mitigated the square previous study. The current study introduces model simulating dynamics prism coupled with ball-in-track (BIT) NES and predicting system behaviou...

CONTEXT Glioma is a malignant brain tumor with rapid proliferation, infiltrative growth, poor prognosis and it is chemoresistent. Pomegranate seed oil (PSO) has antioxidant, anti-inflammatory and antitumor properties. This study showed the optimization of PSO nanoemulsions (NEs) as an alternative for glioma treatment. OBJECTIVE The study aimed to evaluate PSO NEs cytotoxicity on human blood c...

Proteins and ribonucleoproteins containing a nuclear export signal (NES) assemble with the exportin Xpo1p (yeast CRM1) and Gsp1p-GTP (yeast Ran-GTP) in the nucleus and exit through the nuclear pore complex. In the cytoplasm, Yrb1p (yeast RanBP1) displaces NES from Xpo1p. Efficient export of NES-cargoes requires Yrb2p (yeast RanBP3), a primarily nuclear protein containing nucleoporin-like phenyl...

Signal-dependent nuclear protein export was studied in perforated nuclei and isolated nuclear envelopes of Xenopus oocytes by optical single transporter recording. Manually isolated and purified oocyte nuclei were attached to isoporous filters and made permeable for macromolecules by perforation. Export of a recombinant protein (GG-NES) containing the nuclear export signal (NES) of the protein ...