Neurilemmoma of the orbit is a localized, encapsulated, benign nerve sheath tumour which grows very slowly and possibly intermittently, and has no distinctive clinical features (Reese, I963). When large enough it causes exophthalmos and sometimes blurring of vision through pressure on the optic nerve (Reese, I963; Sharma and Kulshrestha, I961). The motility of the eyeball may also be impaired. ...

Neurilemmoma also known as schwannoma is benign nerve sheath tumor rarely occurring in the oral cavity. Only 1% of all extracranial schwannomas show that intraoral occurrence with tongue is the commonest site and retromolar region is the least common site. It presents as encapsulated, slow growing, solitary, smooth-surfaced, usually asymptomatic tumor. We report a case of 70-year-old male with ...

A spinal neurofibroma with malignant change leading to `sarcomatous meningitis' is described in a woman of 73. Three similar cases have been found in the literature. This is an exceedingly rare complication of nerve sheath tumours in the spinal canal.

5 à 10% des patients atteints de neurofibromatose de type 1 (NF1) développent des tumeurs malignes des gaines des nerfs périphériques (Malignant peripheral nerve sheath tumor: MPNST) contre 0.001% dans la population générale. A travers deux observations et une revue de la littérature nous discuterons la spécificité de la transformation sarcomateuse au cours de la neurofibromatose de type 1. Pan...

Malignant peripheral nerve sheath tumor (MPNST) is a rare nerve sheath tumor derived from Schwann cells or pleuripotent cells of neural crest. Neurogenic tumors make about 10-20% of all mediastinal tumors. Incidence of MPNST is 0.001% in general population and 0.16% in patients with neurofibromatosis I (NF I). We report a case of 60 year female presenting with progressive cough and breathlessne...

Familial melanoma-astrocytoma syndrome is a tumor predisposition syndrome caused by inactivating germline alteration of the CDKN2A tumor suppressor gene on chromosome 9p21. While some families with germline CDKN2A mutations are prone to development of just melanomas, other families develop both melanomas, astrocytomas, and occasionally other nervous-system neop...

objective(s): to investigate the effect of topical administration of alpha-lipoic acid into chitosan conduit on peripheral nerve regeneration using a rat sciatic nerve transection model. materials and methods: forty five wistar rats were divided into three experimental groups randomly. a 10-mm gap of sciatic nerve was bridged with a chitosan conduit following surgical preparation and anesthesia...

background:   valproic acid (vpa) is used to be an effective anti-epileptic drug and mood stabilizer. it has recently been demonstrated that vpa could promote neurite outgrowth, activate the extracellular signal regulated kinase pathway, and increases bcl-2 and growth cone-associated protein 43 levels in spinal cord. in the present research we demonstrate the effect of vpa on peripheral nerve r...