account for approximately 3% of all biceps tendon ruptures. The two-incision repair techniques, as described by Boyd and Anderson1 in 1961, were developed to lower the risk of injury to the radial nerve and posterior interosseous nerve. Reports of posterior interosseous nerve palsy following this approach are rare.2-3 Transient posterior interosseous nerve palsies following a repair with the tw...

Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research. Advances in basic research in recent years have increased our understanding of the anatomy of peripheral nerves and the importance of the microenvironment. Various new intervention methods have been developed, but with varying effec...

Traumatic injuries of the peripheral nerves are very common. Surgical repair of the damaged nerve is often complicated by scar tissue formation around the damaged nerve itself. The main objective of this study is to present the recent data from animal experimental studies where pharmacological topical agents are used at the site of peripheral nerve repair. Some of the most commonly topical agen...

Advances in treating peripheral nerve lesions have resulted from research in nerve regeneration and the use biomaterials as well as synthetic materials. When direct tensionless repair of peripheral nerve lesions is not possible, nerve conduits may be used to bridge digital sensory nerve gaps of ≤3 cm. Nerve autograft is the benchmark for larger, longer, mixed, or motor nerve defects. Biologic, ...

Guillain-Barré syndrome (GBS) is a monophasic immune neuropathic disorder in which a significant proportion of patients have incomplete recovery. The patients with incomplete recovery almost always have some degree of failure of axon regeneration and target reinnervation. Anti-ganglioside antibodies (Abs) are the most commonly recognized autoimmune markers in all forms of GBS and specific Abs a...

Peripheral nerve injuries (PNIs) present a serious medical concern, constituting approximately 100,000 neurosurgical procedures in the US and Europe annually. Despite this large number, only 50% of patients achieve good to normal restoration of function following surgical repair. This is due to current insufficiencies with PNI repair strategies to treat major nerve trauma, defined as loss of a ...

Peripheral nerve trauma results in functional loss in the innervated organ, and recovery without surgical intervention is rare. Many surgical techniques can be used for nerve repair. Among these, the tubulization technique can be highlighted: this allows regenerative factors to be introduced into the chamber. Cell therapy and tissue engineering have arisen as an alternative for stimulating and ...