BACKGROUND The recent identification of the cold-menthol sensory receptor (TRPM8; CMR1), provides us with an opportunity to advance our understanding of its role in the pathophysiology of bladder dysfunction, and its potential mediation of the bladder cooling reflex. In this study, we report the distribution of the cool and menthol receptor TRPM8 in the urinary bladder in patients with overacti...

The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. Current clinically approved hollow nerve guidance conduits allow provision of this protective environment; however they fail to provide an essential internal architecture t...

In rat sympathetic ganglia decentralization by preganglionic denervation leads to intraganglionic sprouting of adrenergic nerve and also in an intraganglionic increase of peptidergic fibres immunoreactive (IR) for substance P (SP) and calcitonin gene-related peptide. We explored the time-course of the post-denervation changes in intraganglionic nerve fibres immunoreactive for calcitonin gene-re...

Burning mouth syndrome (BMS) is often an idiopathic chronic and intractable pain condition, affecting 1.5-5.5% of middle-aged and elderly women. We have studied the heat and capsaicin receptor TRPV1, and its regulator nerve growth factor (NGF), in BMS. Patients with BMS (n=10) and controls (n=10) were assessed for baseline and post-topical capsaicin pain scores, and their tongue biopsies immuno...

The VIIth cranial (facial) nerve is largely motor in function (some sensory fibres from external acoustic meatus, fibres controlling salivation and taste fibres from the anterior tongue in the chorda tympani branch). It also supplies the stapedius (so a complete nerve lesion will alter auditory acuity on the affected side). From the facial nerve nucleus in the brainstem, fibres loop around the ...

Medial gastrocnemius and sural nerves in one hindlimb of the cat were transected and prevented from regenerating. After periods ranging from 29-273 days, compound action potentials were recorded from axotomised and contralateral control nerves. The amplitude and integrated area of action potentials decreased and conduction velocity slowed following axotomy. The area under compound action potent...

Serial electrophysiological studies were performed in a case of 'tourniquet paralysis' of the upper limb after the application of an Esmarch bandage above the elbow. Three months after onset of paralysis, nerve conduction was reduced to a quarter of normal between elbow and and axilla along the few fibres still conducting through the lesion, but was normal distal to the block. Seven months afte...

The differential nerve block produced by ischaemia has been used in an attempt to identify the afferent nerve fibres responsible for vibratory inhibition of the monosynaptic reflex in man. It is concluded that the inhibition arises mainly from receptors in the lower leg and is carried by myelinated afferent fibres larger than A-delta.

BACKGROUND Haemangiomas of the head or face are a frequent vascular pathology, consisting in an embryonic dysplasia that involves the cranial-facial vascular network. Haemangiomas show clinical, morphological, developmental and structural changes during their course. METHODS The clinical characteristics of head-facial haemagiomas were studied in 28 individuals (9 males and 19 females) admitte...

Thirty nine patients with unilateral lumbar nerve root compression at one level were examined with quantitative sensory testing immediately before microdiscectomy and at six weeks, fourmonths, and 12 months after surgery. Twenty one healthy volounteers were used as controls. The patients were classified as having a good or a poor result at the one year follow up. The improvement of function in ...