objective: to assess the neuroprotective effects of local administration of 17- beta- estradiol on nerve regeneration. methods: sixty female wistar rats were overiectomized and divided into four experimental groups (n = 15), randomly: in autograft group a segment of sciatic nerve was transected and re-implanted reversely. in sham-surgery group sciatic nerve was exposed and manipulated. in trans...

To date, reliable data to support the general use of biodegradable materials for bridging nerve defects are still scarce. We present the outcome of nerve regeneration following type I collagen conduit nerve repair in patients with large-diameter nerve gaps. Ten patients underwent nerve repair using a type I collagen nerve conduit. Patients were re-examined at a minimal follow-up of 14.0 months ...

INTRODUCTION Previously, we introduced the biogenic conduit (BC) as a novel autologous nerve conduit for bridging peripheral nerve defects and tested its regenerative capacity in a short- and long-term setting. The aim of the present study was to clarify whether intraluminal application of regeneration-promoting glial cells, including Schwann cells (SC) and olfactory ensheathing cells (OEC), di...

ObjectiveTo study local effect of prostaglandin E1on sciatic nerve regeneration DesignExperimental study AnimalsSixty male healthy white Wistar rats ProceduresSixty animals were divided into four experimental groups (n = 15), randomly: Trasnsected (TC), Sham-operation (SHAM), control (CHIT) and prostaglandin E1treated (CHIT/PGE) groups. In SHAM group after anesthesia left sciatic nerve was expo...

A major problem hindering the development of autograft alternatives for repairing peripheral nerve injuries is immunogenicity. We have previously shown successful regeneration in transected rat sciatic nerves using conduits filled with allogeneic dorsal root ganglion (DRG) cells without any immunosuppression. In this study, we re-examined the immunogenicity of our DRG neuron implanted conduits ...

Silk Fibers has emerged as a versatile biomaterial for regenerative medicine. In article 2203237, Christine Radtke and co-workers use silk-based nerve conduit filled with spider silk fibers to treat rat sciatic defect. The silk-in-silk achieves similar performance the current gold standard, autograft, represents promising approach reconstruction.

The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. Current clinically approved hollow nerve guidance conduits allow provision of this protective environment; however they fail to provide an essential internal architecture t...

Traumatic injuries resulting in peripheral nerve lesions often require a graft to bridge the gap. Although autologous nerve auto-graft is still the first-choice strategy in reconstructions, it has the severe disadvantage of the sacrifice of a functional nerve. Cell transplantation in a bioartificial conduit is an alternative strategy to create a favourable environment for nerve regeneration. We...

OBJECTIVE To determine the effects of local administration of platelet rich plasma (PRP) on peripheral nerve regeneration in rat sciatic nerve transection model. METHODS Forty-five male white Wistar rats were randomized into three experimental groups (n=15): Normal control group (NC), silicon group (SIL), PRP treated group (SIL/PRP). In NC group left sciatic nerve was exposed through a glutea...

Peripheral nerve injury is a debilitating condition for which new bioengineering solutions are needed. Autografting, the gold standard in treatment, involves sacrifice of a healthy nerve and results in loss of sensation or function at the donor site. One alternative solution to autografting is to use a nerve guide conduit designed to physically guide the nerve as it regenerates across the injur...