The audiological or physiological data showed that auditory neuropathy was due to the demylination disease in peripheral nerve, especially in auditory nerve. The aim of this study was to explore the changes of auditory function and auditory nerve pathology through establishing a guinea pig model with demyelinated peripheral nerve. The guinea pig model was established by immunizing guinea pigs w...

1-[(2-adamantyl)amino]acetyl-2-cyano-(S)-pyrrolidine, monohydrochloride (PKF275-055), a vildagliptin analog, is a novel, selective, potent, orally bioavailable, and long-acting dipeptidyl peptidase IV inhibitor. We studied the effect of PKF275-055 administration on the prevention, protection, and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat. PKF275-055 improved bo...

We welcome the commentary of Ziegler et al. (1) and are delighted to have the opportunity to clarify certain details of the study that were included in our first submission but had to be omitted because of article length restrictions. We don’t agree with the statement that because the number of subjects included with confirmed diabetic sensorimotor polyneuropathy (DSPN) was presumably low, our ...

Reactive oxygen species (ROS) are elevated by metabolic changes in diabetes, including autoxidation and increased advanced glycation. Endogenous protection by the glutathione redox cycle is also compromised by the competing NADPH requirement of elevated polyol pathway flux. Antioxidant treatment strategies prevent or reverse nerve conduction velocity (NCV) deficits in diabetic rats. These inclu...

1-Deoxysphingolipids (1-deoxySLs) are atypical neurotoxic sphingolipids that are formed by the serine-palmitoyltransferase (SPT). Pathologically elevated 1-deoxySL concentrations cause hereditary sensory and autonomic neuropathy type 1 (HSAN1), an axonal neuropathy associated with several missense mutations in SPT. Oral L-serine supplementation suppressed the formation of 1-deoxySLs in patients...

OBJECTIVE To investigate the effect of surgical decompression on painful diabetic peripheral neuropathy (DPN) patients and discuss the role which pain distribution and characterization play in the management of painful DPN as well as the underlying mechanism involved. METHODS A total of 306 patients with painful diabetic lower-extremity neuropathy were treated with Dellon surgical nerve decom...

AIMS/INTRODUCTION Despite being the most common complication of diabetes, the pattern of clinical development of diabetic neuropathy is not well-known. In the present study, we retrospectively examined sequential changes in nerve conduction studies (NCS) for 4 years to characterize the way neuropathic changes develop in patients with type 2 diabetes. MATERIALS AND METHODS We randomly selected...

Delayed neurotoxic complications of chemical warfare agents (CWA), such as sulphur mustard (SM) and tabun, in human beings have not been reported in detail. We thus aimed to investigate possible neurotoxic complications of these agents in Iranian veterans 22-27 years after exposure. After co-ordination with the veteran foundation and obtaining the approval of the medical research ethics committ...

Although it is a well-established fact that dietary fish oil can improve nerve conduction velocity in diabetic rat, but the exact mechanism of its action is unknown. Therefore, in this study we measured the blood glucose level of all animals for evaluating the possible effect of fish oil in improvement of nerve conduction velocity in diabetic neuropathy via regulation of blood glucose level. Fo...

Although it is a well-established fact that dietary fish oil can improve nerve conduction velocity in diabetic rat, but the exact mechanism of its action is unknown. Therefore, in this study we measured the blood glucose level of all animals for evaluating the possible effect of fish oil in improvement of nerve conduction velocity in diabetic neuropathy via regulation of blood glucose level. Fo...