Electrophysiological testing remains an important efficacy parameter in clinical neuropathy trials. The quality of nerve conduction studies in reported trials varies greatly, and may be responsible for negative results. We report the utilization of an expert core lab for electrophysiological testing. With the core lab, the variability of repeat testing is comparable to that of a single, excelle...

Histological and electrophysiological studies were performed on Lewis rats with acute experimental allergic encephalomyelitis (EAE) induced by inoculation with guinea-pig myelin basic protein (MBP) and Freund's adjuvant. The histological studies showed demyelination in the lumbar, sacral and coccygeal dorsal and ventral spinal roots and to a lesser extent in the spinal cord, including the dorsa...

The peroneal nerve anatomy of the rabbit distal hindlimb is similar to humans, but reports of distal peroneal nerve conduction studies were not identified with a literature search. Distal sensorimotor recordings may be useful for studying rabbit models of length-dependent peripheral neuropathy. Surface electrodes were adhered to the dorsal rabbit foot overlying the extensor digitorum brevis mus...

Studies in experimental diabetic rat attribute the acute reversible nerve conduction defect as well as the early structural abnormalities of the node of Ranvier and myelinated axons to changes in nerve metabolism secondary to hyperglycaemia and activation of the pol yo1 pathway.’-8 The early readily reversible slowing of nerve conduction velocity in the diabetic rats correlates with a decrease ...

INTRODUCTION Carpal Tunnel Syndrome (CTS) is the most common nerve entrapment. Subjective sensory symptoms are common place in patients with CTS, but sometimes they are not supported by objective findings in the neurological examination. Electrodiagnostic (EDx) studies are a valid and reliable means of confirming the diagnosis. The amplitudes along with the conduction velocities of the sensory ...

OBJECTIVE Our aim was to investigate the prevalence of intra-operative nerve damage and its association with chronic pain. METHODS Our prospective study of 33 patients used nerve conduction studies to assess intercostal nerve function during elective thoracic surgical procedures. We used two methods to study nerve conduction: pre-operative magnetic stimulation (in 10 patients) and intra-opera...

185 www.ijbamr.com “Effect of human occupational exposure to organic solvents: An Electrophysiological Study.” *Reshu gupta **Abhishek Kawatra, ***K C Mathur , #BK Binawara, ##Rajniesh Sharma ^ Arvind Vyas ..................................................................................................................................... ABSTRACT: Introduction: Exposure to solvents is ubiquitou...

Introduction Abnormal neural impulses in the nervous system may lead to various diseases and disabilities. High frequency alternating currents (HFAC) has been used to block the propagation of such impulses and improve the symptoms or disabilities. The technique is safe, reversible, and relatively selective, and its reliability, the optimum stimulation parameters, and elimination of the onset re...

background: incidence and predominant subtype  of guillain-barre syndrome (gbs) differs geographically. electrophysiology has an important  role in early diagnosis and  prediction  of prognosis. this study  is conducted to determine the frequent  subtype  of gbs in a large group of patients  in iran and compare  nerve conduction studies in axonal and demyelinating forms of gbs. methods:    we  ...

The sensitivity and specificity of nerve conduction studies and needle electromyography for the diagnosis of ulnar neuropathy at the elbow were evaluated by a critical review of the literature. With a search of the medical literature in English through January 1996, 101 articles were identified and reviewed on the basis of six criteria of scientific methodology. The findings of 6 articles that ...