Neonatal alloimmune thrombocytopenia (NAIT) can cause severe bleeding in the central nervous system (CNS) and death or severe neurologic sequelae. The expression of the PLA1 antigen is detectable as early as 1 9 weeks of gestation. Alloimmunization can therefore lead to fetal thrombocytopenia very early in pregnancy. Until recently. we have had no means of detecting and assessing the severity o...

Fetal and neonatal alloimmune thrombocytopenia constitutes the most common cause of severe thrombocytopenia in fetuses and neonates and of intracranial hemorrhage among term newborns. The cornerstone of therapy involves the use of steroids and intravenous immunoglobulins. Despite the risk of potentially devastating consequences to the fetus, fetal blood sampling has typically been used to docum...

OBJECTIVES To evaluate the safety of vaginal delivery in pregnancies with fetal and neonatal alloimmune thrombocytopenia (FNAIT). DESIGN Prospective data collection. SETTING Leiden University Medical Centre, the national centre for management of severe red cell and platelet alloimmunisation. POPULATION Thirty-two pregnancies with FNAIT, with a sibling with thrombocytopenia but without an ...

SYMPTOMATI C thrombocytopenia occurring in the neonatal period is a potentially serious disorder resulting in death in approximately 14 per cent of reported cases.1'2 Some affected infants are born of mothers who have, or have had, idiopathic thrombocytopenic purpura (ITP) In these cases it is assumed that a thrombocytopenic factor is transmitted to the fetus across the placenta, but the nature...

Bleeding problems often occur during the neonatal period. Although thrombocytopenia is the most common cause, coagulation problems often occur, and the two problems may co-exist. The causes, diagnosis, and management of coagulation problems in newborn infants are reviewed.

Objectives: To determine the frequency of thrombocytopenia in culture-positive neonatal sepsis. Methodology: This hospital-based cross-sectional study was conducted at a tertiary care hospital Pakistan be­tween July to December 2021 Department Pediatrics, National Institue Child Health Karachi - Pakistan. All neonates admitted NICU with signs and symptoms sepsis positive blood culture were enro...

Survival rates for infants born prematurely have improved significantly, in part due to better supportive care such as RBC transfusion. The role of platelet transfusions in neonates is more controversial. Neonatal thrombocytopenia is common in premature infants. The primary causal factors are intrauterine growth restriction/maternal hypertension, in which the infant presents with thrombocytopen...