Congenital hyperinsulinemic hypoglycemia (CHI) is the common cause of severe hypoglycemia in infancy. Profound hypoglycemia requires appropriate diagnosis and aggressive treatment to prevent severe and irreversible brain damage. Here we report 21 Japanese hypoglycemia cases with severe hyperinsulinemia. We report 16 CHI cases, 2 HIHA cases, 1 GSD1b case and 2 PSS cases. 12 cases of CHI had seve...

PURPOSE To investigate whether planning of pregnancy in women with epilepsy affects seizure control during pregnancy and to compare the maternal and neonatal outcomes in planned and unplanned pregnancies. METHODS This was a retrospective cohort study of 153 pregnant women with epilepsy who were treated at the University of Tsukuba Hospital and Hokkaido University Hospital between 2003 and 201...

Abstract Background and objective Phenobarbitone is used as a first-line drug for neonatal seizures. However, its poor short- long-term safety profile concerning. We aim to systematically synthesize the data on efficacy of phenobarbitone agent compare it against other anti-epileptic drugs (AEDs) in neonates. Methods Using keywords related study population (neonatal seizure) intervention (phenob...

Automated processing and analysis of video recordings of neonatal seizures can generate novel methods for extracting quantitative information that is relevant only to the seizure [5], [6]. This information can be used to: 1) develop automated mechanisms capable of detecting the beginning of clinical seizures, 2) refine the characterization of repetitive motor behaviors, and 3) facilitate the di...

Background: Neonatal seizure is a paroxysmal behavior caused by hyper-synchronous discharge of group neurons. seizures are the most common overt manifestation neurological dysfunction in newborn. The electroencephalography (EEG) an important tool evaluation infant with symptoms referable to central nervous system. It provides excellent and non-invasive method assessing at risk newborns formulat...

OBJECTIVE Simple Febrile Seizure (SFS) is the most common seizure disorder in childhood, and is frequently described as inoffensive disorder. Nevertheless, there is evidence suggesting the association between neonatal febrile seizures and hippocampal abnormalities in adulthood. This study was conducted at evaluating the hippocampal expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 protei...

OBJECTIVE The aim of this study is to apply a real-time algorithm for clonic neonatal seizures detection, based on a low complexity image processing approach extracting the differential average luminance from videotaped body movements. METHODS 23 video-EEGs from 12 patients containing 78 electrographically confirmed neonatal seizures of clonic type were reviewed and all movements were divided...

how to cite this article: saeedi borujeni mj, hami j, haghir h, rastin m, sazegargh. evaluation of bax and bcl-2 proteins expression in the rat hippocampus due to childhood febrile seizure. iran j child neurol. winter 2016; 10(1):53-60. abstract objective simple febrile seizure (sfs) is the most common seizure disorder in childhood, and is frequently described as inoffensive disorder. neverthel...