Serial plasma glucose concentrations were compared in 20 infants of low birthweights (< 2500 g) after test meals of 10% solutions of Caloreen and glucose. After Caloreen, the rise in plasma glucose concentration occurred more slowly but was better sustained, and hyperglycaemia was seen less often than after glucose. Caloreen may be preferable to glucose as a carbohydrate source in the prophylax...

An infant of 31 weeks' gestation presented with refractory neonatal hypoglycaemia secondary to islet cell dysregulation. Treatment was started with somatostatin analogue and his glycaemic control improved initially. Tolerance developed, however, in that the dose required to maintain control increased by a factor of 40. The infant subsequently underwent pancreatectomy. It is safe to use somatost...

INTRODUCTION Late preterm (LP) neonates (34 to 36 weeks gestation) are often managed like term neonates though current literature has identified them to have greater complications. The primary objective of our study was to evaluate and compare morbidity and resource utilisation in LPs especially in view of paucity of Asian studies in this regard. MATERIALS AND METHODS A retrospective audit wa...

BACKGROUND Hepatocyte nuclear factor 4α (HNF4A) is a member of the nuclear receptor family of ligand-activated transcription factors. HNF4A mutations cause hyperinsulinaemic hypoglycaemia in early life and maturity-onset diabetes of the young. Regular screening of HNF4A mutation carriers using the oral glucose tolerance test has been recommended to diagnose diabetes mellitus at an early stage. ...

HYPOGLYCAEMIA in children may cause listlessness, inattention, pallor, stupor, convulsions and coma, which may be accompanied by tachycardia and sweating. Such non-specific symptoms as cyanotic attacks, reluctance to feed, irritability, convulsions, jittery limb movements and depression of the Moro reflex may occur in the hypoglycaemic newborn infant. A major part of these clinical patterns ari...

The importance of hypoglycaemia, defined as a true blood glucose below 20 mg./100 ml., in the newborn infant is now well recognized. It is sometimes found in the idiopathic respiratory distress syndrome (RDS), in infants of diabetic mothers, and in neonatal cold injury, and it may also occur in association with anoxia, cerebral haemorrhage, or infection (Neligan, 1965). The majority of symptoma...