Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a therapeutic agent has been access to sufficient amounts of material for biological testing. Although there are two reported syntheses of neo, bot...

Himalayan rivers have very unusual Sr characteristics and their budget cannot be achieved by simple mixing between silicate and carbonate even if carbonates are radiogenic. We present Sr, O, and C isotopic data from river and rain water, bedload and bedrock samples for the western and central Nepal Himalaya and Bangladesh, including the monsoon season. Central Himalayan rivers receive Sr from s...

Antihemorroidal hubber Leuco hubber Panotile Bacisporín Linitul antibiótico Poly-pred Bexicortil Liquipom dexa-antibiótico Pomada antibiótica liade Bio-hubber/fuerte Maxitrol Positon crema Blastoestimulina óvulos Neo-analsona Positon crema Blastoestimulina pomada Neo-bacitrin Potison loción Creanolona Neo-bacitrin hidrocortisona Positon ungüento Decadran neomicina Neo-hubber Rinobanedif Deltaci...

Rhodopsin is formed by the condensation of opsin with a cis isomer of retinene, called neo-b. The bleaching of rhodopsin releases all-trans retinene which must be isomerized back to neo-b in order for rhodopsin to regenerate. Both retinene isomers are in equilibrium with the corresponding isomers of vitamin A, through the alcohol dehydrogenase system. An enzyme is found in cattle retinas and fr...

A new ascothoracidan species, Gorgonolaureus bicornutus sp. nov., has been discovered off south-eastern Taiwan at a depth of 227 m. Five females were found in permanent cysts on the branches of a plexaurid octocoralian alcyonacean (former "gorgonian"), Echinogorgia sp. These specimens are assigned to the genus Gorgonolaureus on account of their having an enlarged and inflated carapace with a lo...

The Upper Jurassic to Lower Cretaceous shallow water platform carbonates of the Northern Calcareous Alps (Plassen Formation, “Lärchberg Formation”) and the resedimented deposits of the latter within basinal series (Barmstein Limestone, Tressenstein Limestone) are currently under re-investigation (SCHLAGINTWEIT et al., 2003; GAWLICK et al., 2005). This shallow water development is directly linke...

Die Anwendung Remote Task Control entstand in Zusammenarbeit der Firmen HORSCH und geo-konzept im Forschungsprojekt Geo Farm und ermöglicht eine durchgängig automatisierte Prozesskette von der Bereitstellung und Archivierung georeferenzierter Applikationskarten und Datenübertragung zur Landmaschine bis zur Ausführung und Dokumentation des variablen Applikationsprozesses im Feld. Das Projekt Geo...

objectives: multiple sclerosis is an incurable and chronic disease of the central nervous system. the main purpose of this survey is to compare the character types and life expectancy of patients suffering from m. s as compared with normal people. this survey was conducted using the persian translation of neo-ffi (neo-five factor inventory) and herth life expectancy. methods:thirty nine people ...

In most phylogenetic lineages, the evolution of sex chromosomes is accompanied by their heteromorphization and degradation of one of them. The neo-sex chromosomes are useful model for studying early stages of these processes. Recently two lineages of the neo-sex chromosomes on different stages of heteromorphization was discovered in Pamphagidae family. The neo-sex chromosome heteromorphization ...