background: n-terminal pro-brain natriuretic peptide (nt-probnp) is a sensitive biomarker for the detection of asymptomatic left ventricular (lv) dysfunction. since β-thalassemia major patients suffer from early diastolic dysfunction due to iron deposition of chronic blood transfusion, we tried to evaluate the correlation between the serum nt-probnp level and the severity of lv diastolic dysfun...

background respiratory distress syndrome (rds) is considered as one of the most popular prematurity-related respiratory problems and among the most prominent reasons of deaths in preterm infants. objectives brain natriuretic peptide (bnp) is the secret of the volume and pressure overload response of the vessels and decreases due to resistance as well as rises in systemic vessels and also in dec...

Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Renal dopamine plays a central role in this interactive network. The natriuretic hormones, such as the atrial natriuretic peptide, mediate some of their effects by affecting the renal dopaminergic system. Renal do...

Among the comorbid conditions that significantly worsen quality of life and expectancy are chronic obstructive pulmonary disease heart failure. Difficulties drug therapy mutually exclusive approaches in treatment concomitant cardiovascular pathology. Aim this study was to provide scientific evidence possible use combined LCZ696 (angiotensin receptor neprilysin inhibitor, ARNI), which contains i...

BACKGROUND Preeclampsia and its complications may be associated with elevated B-type natriuretic peptide levels during and after pregnancy. METHODS We conducted a systematic review to determine whether preeclampsia and/or related cardiovascular complications, eclampsia and preterm delivery are associated with elevated natriuretic peptide levels. Three bibliographic databases were searched, us...

In contrast to the wealth of information available concerning the response of plasma atrial natriuretic peptide to changes in pressure and volume status and to inhibition of endopeptidase 24.11, very little is known of possible concomitant effects on brain natriuretic peptide. The effects of change in posture, pressor infusions of angiotensin II, or inhibition of endopeptidase 24.11 were docume...

1. Atrial natriuretic peptide and brain natriuretic peptide have similar vasodilator and natriuretic properties, although little information is available regarding their relative effects as antagonists of the renin-angiotensin-aldosterone system. We have therefore compared how atrial natriuretic peptide and brain natriuretic peptide affect the systemic pressor and aldosterone responses to angio...

Atrial natriuretic peptide (ANP) potentiates vagal cardiopulmonary reflexes due to chemosensory (Bezold-Jarisch [B-J] reflex) or mechanosensory (ramp baroreflex) activation. The ANP receptor mediating these actions is unknown. We examined the role of particulate guanylyl-cyclase (pGC) receptors in ANP-induced enhancement of cardiopulmonary vagal reflexes. Cardiopulmonary baroreceptor reflex fun...

Brain-Derived Neurotrophic Factor (BDNF) is a neuroprotectant candidate for neurodegenerative diseases. However, there are several clinical concerns about its therapeutic applications. In the current study, we selected BDNF-mimicking small peptides from phage-displayed peptide library as alternative molecules to the clinical challenges. The peptide library was screened against BDNF receptor (Ne...

To characterize the type of cell expressing natriuretic peptide receptors in the brain and the nature of these receptors, we conducted studies in primary cultured glial and neuronal cells derived from fetal rat diencephalon. The glial predominant cultures (95% of total cells and glial fibrillary acidic protein positive) expressed nearly a 10-fold greater specific binding of the natriuretic pept...