N-Acetyltransferases (NATs) play an important role in the biotransformation of a wide variety of arylamine drugs and carcinogens. Two genes (NAT1, NAT2) have been identified and allelic variation in NAT2 has been associated with arylamine toxicity in adults. Little information has been reported on expression of NAT genes during embryonic and fetal development although substrate specific NAT act...

FURTHER READINGS Bosco D et al: Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci, 11:1396, 2010 Bruijn LI, Cudkowicz M: Therapeutic targets for amyotrophic lateral sclerosis: Current treatments and prospects for more effective therapies. Expert Rev Neurother 6:417, 2006 Digiorgio et al: Non-cell autonomous effect of glia on motor neur...

Hydralazine is used in the treatment of essential hypertension and is under investigation for epigenetic therapy in the treatment of neoplastic and renal diseases. N-acetyltransferase (NAT) 2 exhibits a common genetic polymorphism in human populations. After recombinant expression in yeast, human NAT2 exhibited an apparent Lineweaver-Burk constant (K-m) value (20.1 ± 8.8 μM) for hydralazine ove...

Shikonin has the potential to prevent, or be used in the treatment of, bladder transitional cell carcinoma induced by arylamines. We evaluated its effectiveness by measuring the amount of acetylated 2-aminofluorene (AF), AF-DNA adducts, changes of NAT mRNA and the amount of NAT enzyme. T24 human bladder cancer cells were incubated with 30 microM AF with different concentrations of shikonin for ...

If a host is located behind a NAT, then in certain situations it can be impossible for that host to communicate directly with other hosts (peers). In these situations, it is necessary for the host to use the services of an intermediate node that acts as a communication relay. This specification defines a protocol, called TURN (Traversal Using Relays around NAT), that allows the host to control ...

Network Address Translator (NAT) is a technology that is used for allowing multiple computers in the network to share a single public IP address for accessing the Internet. The basic reason for NAT usage is the limited number of IPv4 addresses. NAT is widely used in the current networks where it is also used as cloaking service for computers in internal network, since all computers behind the N...

Chromosome location: The location of the canine gene is unknown; the corresponding human gene maps to 17q21 (Law et a1. 1986). or to 17ql1.1-q12 (Xu et a1. 1988). Acknowledgement: This work was supported by a grant from the American Kennel Club. References Hogg D. et a1. (1986J JBioI Chern 261,12420-7. Law M.L. et al. (1986J Cytogenet Cell Genet 42,202-7. Xu W. et al. (1988J Proc Nat! Acad Sci ...

This paper proposes a new method for Network Address Translator (NAT) Traversal in UDP. Several techniques have been proposed for traversing NAT or firewall boxes in UDP. These techniques can establish UDP communication between hosts behind NATs. However, existing NAT traversal methods, including Universal Plug and Play (UPnP), Simple traversal of UDP over NATs (STUN) and Teredo, cannot travers...

The effect of a recombination event in the genomic 3' end on the biological properties and competitiveness of plum pox virus (PPV) was investigated. Therefore, a fragment spanning the coat protein (CP) coding region and a part of the 3' non-translated region of a non-aphid-transmissible strain of PPV (PPV-NAT) was replaced by the corresponding region of a PPV sour cherry isolate (PPV-SoC). The ...