Risk assessment for natalizumab-associated progressive multifocal leukoencephalopathy (Nat-PML) comprises the anti-JC virus (JCV) antibody index (AI). The anti-JCV AI was longitudinally determined in a natalizumab-treated MS cohort (Nat-MS, n = 468) and samples of Nat-PML patients (n = 15). In Nat-MS, the median AI was 0.8 (25th to 75th percentile, 0.2-2.8) with an intra-individual coefficient ...

A scheme for introducing mountain wave-induced temperature pertubations in a microphysical PSC model has been developed. A data set of temperature fluctuations attributable to mountain waves as computed by the Mountain Wave Forecast Model (MWFM-2) has been used for the study. The PSC model has variable microphysics, enabling different nucleation mechanisms for nitric acid trihydrate, NAT, to be...

Background. Introduction of nucleic acid testing (NAT) has helped in decreasing window period donations, resulting in increased safety of blood supplies. NAT combines the advantages of direct and highly sequence-specific detection of viral genomes. We analysed the performance of newer Procleix Ultrio Elite (PUE) and Procleix Ultrio assay (PUA) for the screening of the viral markers in our donor...

Blood screening by NAT for major transfusion transmitted viral infections (TTIs) was originally intended to complement serology for detection of infected donations. Reports from developed countries showed limited marginal value to NAT blood screening in improving blood safety. Reports on NAT results from Europe indicated yield of 1:0.6 million donations for HBV, <1:M for HCV and HIV-1-related t...

[1] The contribution of stratospheric mountain waves to the formation of large nitric acid trihydrate (NAT) particles and subsequent denitrification of the Arctic polar vortex is calculated for the 1999/2000 winter using a three-dimensional (3-D) model. The model production mechanism involves the formation of NAT clouds with high particle number concentrations downwind of mountain wave ice clou...

Eason, R., Cline, M. J. & Smellie, R. M. S. (1963). J. biol. Chem. 238, 3978. Eason, R. & Smellie, R. M. S. (1965). Biochem. J. 94, 7P. Geiduschek, E. P., Moohr, J. W. & Weiss, S. B. (1962). Proc. nat. Acad. Sci., Wash., 48, 1078. Geiduschek, E. P., Tocchini-Valentini, G. P. & Sarnat, M. T. (1964). Proc. nat. Acad. Sci., Wa8h., 52, 486. Green, M. H. (1964). Proc. nat. Acad. Sci., Wash., 52, 138...

ing away from the details, we can see that nat rect is indeed a function with three parameters (the keyword fun is similar the lambda notation and is common in the family of ML-like languages). The body of nat rect is implemented as a recursive function (defined via the keyword fix) taking an argument n of type nat. Internally, it proceeds similarly to our implementation of my plus: if the argu...

Pineal melatonin synthesis is stimulated at night following an increase in arylalkylamine-N-acetyltransferase (AA-NAT) activity. Depending on the species, two mechanisms of enzyme activation have been described: a cAMP/phospho-cAMP response element-binding protein-dependent stimulation of Aa-nat gene transcription in the rat, presumed to occur in all rodents, or a posttranslational regulation o...

Nat-siRNAs (small interfering RNAs originated from natural antisense transcripts) are a class of functional small RNA (sRNA) species discovered in both plants and animals. These siRNAs are highly enriched within the annealed regions of the NAT (natural antisense transcript) pairs. To date, great research efforts have been taken for systematical identification of the NATs in various organisms. H...