In the U.S., nasopharyngeal carcinoma (NpC) kills >7,600 each year. Deaths are predominantly among adult men, and in most cases, early detection and treatment can save lives. Despite the annual spending of approximately 3.2 billion dollars on head and neck cancer research, NpC remains a neglected disease since its fatality rates are among the lowest nation wide. The relative survival rates from...

BACKGROUND BRCC3 has been found to be aberrantly expressed in breast tumors and involved in DNA damage response. The contribution of BRCC3 to nasopharyngeal carcinoma prognosis and radiosensitivity is still unclear. METHODS Immunohistochemical analysis of BRCC3 was carried out in 100 nasopharyngeal carcinoma tissues, and the protein level was correlated to patient survival. BRCC3 expression o...

BACKGROUND & OBJECTIVE Nasopharyngeal carcinoma (NPC) is an epithelial neoplasm with high occurrence rates in southern China. The disease often metastasizes to regional lymphnodes at a very early stage. Local recurrences and metastasis occur frequently in patients with NPC and are a leading cause of death, despite improvements on treatment modalities. The molecular mechanism underlying the meta...

Nasopharyngeal carcinoma (NPC) is a unique disease with a clinical presentation, epidemiology, and histopathology differing from other squamous cell carcinomas of the head and neck. NPC is an Epstein-Barr virus-associated malignancy with a marked racial and geographic distribution. Specifically, it is highly prevalent in southern China, Southeast Asia, and the Middle East. To date, most NPC pat...

Anatomically the cavernous sinus is closely related to the sphenoid sinus and the nasopharynx. Sphenoid sinusitis, as demonstrated in the case can affect the nerves which are contained within it. Apart from the sinus, a direct extension from a nasopharyngeal lesion is commonly encountered to cause diplopia, owing to the sixth nerve involvement. The provisional diagnosis should be a nasopharynge...

PURPOSE Death-associated protein (DAP)-kinase gene is frequently inactivated by promoter hypermethylation in cancer. The aim of this study was to evaluate the promoter methylation status of the DAP-kinase gene in nasopharyngeal carcinoma (NPC). EXPERIMENTAL DESIGN The methylation status was evaluated by methylation-specific PCR (MSP). Thirty-two NPC biopsy specimens, plasma and buffy coat of ...

Nasopharyngeal carcinoma (NPC) differs from others head and neck cancers by many points. Its incidence remains high in some parts of the globe, in southern China, Southeast Asia and North Africa. In North Africa there are two peaks of age-specific incidence, in young (between 10 and 20 years old) and adult patients (50 years old) [1, 2]. Among the three histological types, the Undifferentiated ...

Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck region, which frequently occurs in Southeast Asia, especially in the south of China. It is known that the mammalian target of rapamycin (mTOR) pathway plays a central role in regulating cellular functions, including proliferation, growth, survival, mobility, and angiogenesis. Aberrant expression of the mTOR signaling pathw...

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors head and neck, its incidence highest all around world. Intensive radiotherapy using computer-aided diagnosis best technique for treatment NPC. The key step delineation target areas organs at risk, that is, tumor images segmentation. We proposed segmentation method NPC image based on multi-scale cascaded fully convolutiona...

The purpose of this study was to determine the phenotyping of Peripheral Blood Lymphocytes (PBL) in Head and Neck Cancers (HNCA) patients and to relate this with the level of Cell-Mediated Immunity (CMI) measured by in vitro lymphoproliferative assay, in order to evaluate immune suppression in HNCA patients and its possible mechanisms. Accordingly, one hundred twenty two HNCA patients and 100 c...