Streptococcus pneumoniae is a leading cause of morbidity and mortality among children worldwide and particularly in developing countries. In this study, we evaluated PsaA, a conserved antigen important for S. pneumoniae adhesion to and invasion into nasopharynx epithelia, for its ability to induce protective immunity against S. pneumoniae challenge when delivered by recombinant attenuated Salmo...

Nontypeable Haemophilus influenzae (NTHI) is a major pathogen of otitis media. One of the outer membrane proteins of NTHI, P6, is an antigen common to all strains and is considered as a candidate for mucosal vaccine. To elucidate the possibility of developing a nasal vaccine against nontypeable Haemophilus influenzae (NTHI) and to investigate mucosal immune responses in the middle ear, mice wer...

There are two types of flu vaccines: the injection and the nasal spray. Injectable flu vaccines usually contain inactivated strains of types A and B flu virus and help your body to provide immunity to these two common strains of the flu. The nasal spray vaccine contains a live, but weakened version of the same strains ? but its use isn't currently recommended [2]. Any immunity from these vaccin...

There are two types of flu vaccines: the injection and the nasal spray. Injectable flu vaccines usually contain inactivated strains of types A and B flu virus and help your body to provide immunity to these two common strains of the flu. The nasal spray vaccine contains a live, but weakened version of the same strains ? but its use isn't currently recommended [2]. Any immunity from these vaccin...

Sheena Hailin Wang: Novel Delivery Systems for Nasal Administration of Anthrax Vaccine (Under the direction of Dr. Anthony J. Hickey, Ph.D., D.Sc.) There is current biodefense interest in protection against Anthrax. The inhaled form of anthrax is difficult to diagnose and can be fatal without prompt antibiotic intervention. Prophylactic vaccination has become a critical measure for protection o...

The selection of any specific immunization route is critical when defining future vaccine strategies against a genital infection like Chlamydia trachomatis (C.t.). An optimal Chlamydia vaccine needs to elicit mucosal immunity comprising both neutralizing IgA/IgG antibodies and strong Th1/Th17 responses. A strategic tool to modulate this immune profile and mucosal localization of vaccine respons...

There are two types of flu vaccines: the injection and the nasal spray. Injectable flu vaccines usually contain inactivated strains of types A and B flu virus and help your body to provide immunity to these two common strains of the flu. The nasal spray vaccine contains a live, but weakened version of the same strains ? but its use isn't currently recommended [2]. Any immunity from these vaccin...

There are two types of flu vaccines: the injection and the nasal spray. Injectable flu vaccines usually contain inactivated strains of types A and B flu virus and help your body to provide immunity to these two common strains of the flu. The nasal spray vaccine contains a live, but weakened version of the same strains ? but its use isn't currently recommended [2]. Any immunity from these vaccin...

Subunit intranasal vaccines offer the prospect of inducing combined systemic-mucosal immunity against mucosally transmitted infections such as human immunodeficiency virus. However, although human studies have demonstrated the induction of active immunity, secretory immunoglobulin A (sIgA) responses are variable, and no study has demonstrated protection by accepted vaccine-licensing criteria as...

There are two types of flu vaccines: the injection and the nasal spray. Injectable flu vaccines usually contain inactivated strains of types A and B flu virus and help your body to provide immunity to these two common strains of the flu. The nasal spray vaccine contains a live, but weakened version of the same strains ? but its use isn't currently recommended [2]. Any immunity from these vaccin...