A generalization of the GNS-representation is investigated that represents partial ∗-algebras as systems of operators acting on a partial inner product space (PIP -space). It is based on possibly indefinite B-weights which are closely related to the positive B-weights introduced by J.-P. Antoine, Y. Soulet and C. Trapani. Some additional assumptions had to be made in order to guarantee the GNS-...

Unpreserved nasal sprays are the latest trend in nasal drug delivery. Different technologies are discussed here in the context of mechanically protected systems, which may provide additional benefits. New test protocols are suggested to evaluate the improved microbiological protection that can be achieved.

A generalization of the GNS-representation is investigated that represents partial ∗-algebras as systems of operators acting on a partial inner product space (PIP -space). It is based on possibly indefinite B-weights which are closely related to the positive B-weights introduced by J.-P. Antoine, Y. Soulet and C. Trapani. Some additional assumptions had to be made in order to guarantee the GNS-...

OBJECTIVE To evaluate the efficacy and safety of mometasone furoate nasal spray (NS) for the treatment of nasal polyposis. DESIGN Randomized, double-blind, placebo-controlled, parallel-group, multicenter study. SETTING A total of 24 centers in 17 countries. PATIENTS A total of 310 subjects 18 years or older with bilateral nasal polyps. INTERVENTIONS (1) A 200-microg dose of mometasone f...

Self-collected foam nasal swabs (NS) obtained after instillation of saline spray were compared with nasal washes from immunocompetent subjects during 146 upper respiratory infections (URIs); the sensitivities for reverse transcription (RT)-PCR respiratory virus detection were 95% and 88%, respectively (P = 0.06). The sensitivities from NS collected with and without saline spray during 142 URIs ...

In a double-blind group sequential trial the efficiency of an oxytocin nasal spray in enhancing lactation was studied during the first five days after delivery in women who had given birth prematurely. The cumulative volume of breast milk obtained between the second and fifth days after delivery was 3.5 times greater in primiparas given oxytocin than in primiparas given placebo. There was no si...

The objective of the study was to evaluate the therapeutic efficacy of nicotine nasal solution (NNS) for smoking cessation from the stopping day up to 3 months. We also followed the participants for 2 yrs after ceasing smoking to assess what happens after stopping using NNS. In a placebo-controlled, double-blind, 2 yr prospective study, 157 smokers were given either NNS, one dose containing 1 m...

The authors describe a prospective pilot study designed to investigate the use of topical nasal antifungal spray in addition to systemic steroids and itraconazole in the treatment of allergic fungal sinusitis. Sixteen patients with a history of allergic fungal sinusitis were given fluconazole nasal spray and followed for 3 months. Stabilization or improvement of disease without significant side...

. Manno C, Bonifati C, Torres DD, Campobasso N, Schena FP. Desmopressin acetate in percutaneous ultrasound-guided kidney biopsy: a randomized controlled trial. Am J Kidney Dis. 2011;57:850–5. . Stoof SC, Cnossen MH, de Maat MP, Leebeek FW, Kruip MJ. Side desmopressin (DDAVP) to hemophiliacs: pharmacokinetics and factor VIII responses. Thromb Haemost. 1987;58:1037–9. 5. FDA ALERT [12/4/2007]: De...

BACKGROUND Along with patient history, the physical examination is the key component for any patient encounter. Determining what should be included in the nasal examination is critical. Practicing evidenced-based medicine calls for an integration of the clinical/surgical expertise of the provider, the individual patient's needs and preferences, and the application of the current best medical kn...