PURPOSE Chronic rhinosinusitis with nasal polyps is a chronic inflammatory disease with markedly increased eosinophils, Th2-type lymphocytes, fibroblasts, and goblet cells. Fungi are commonly associated with airway inflammatory diseases, and thymic stromal lymphopoietin (TSLP) is important in the development of Th2 inflammatory responses. The aim of this study was to investigate the interaction...

PATIENT Male, 27. FINAL DIAGNOSIS Recurrent epistaxis. SYMPTOMS Nasal bleeding. MEDICATION -. CLINICAL PROCEDURE -. SPECIALTY Pediatrics and Neonatology. OBJECTIVE Congenital defects/diseases. BACKGROUND Recurrent epistaxis is a common disorder among children and young adults. We report an unusual cause, intranasal supernumerary tooth causing friction with Little's area of the nas...

BACKGROUND Nasal polyposis is characterized by persistent inflammation but the pathogenesis is complex and still debatable. Autophagy has been associated with many human health problems including chronic inflammatory airway diseases. Whether autophagy plays a role in nasal polyps and could be a therapeutic target is completely unknown. METHODS We studied light chain 3 (LC3) protein expression...

BACKGROUND/AIMS We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify a connection between upper airway inflammation and lower airway responsiveness. METHODS We counted eosinophils on nasal smears, and performed spirometry, allergic skin tests, and methacholine...

OBJECTIVE To determine whether non-secretion of blood group antigens is associated with respiratory virus diseases. DESIGN Study of secretor status in patients with respiratory virus diseases determined by an enzyme linked immunosorbent assay (ELISA) developed to identify Lewis (Le) blood group antigen phenotypes (Le(a) non-secretor; Le(b) secretor). SUBJECTS Patients aged 1 month to 90 yea...