Primary pulmonary mucinous adenocarcinoma (PPMA) is an uncommon subtype of lung adenocarcinoma. The present study attempted to clarify the diagnosis, clinicopathological characteristics, and pathologic significance of epithelial growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) mutations and the prognosis of PPMA. A total of 29 patients with PPMA from among 1,469 surgi...

BACKGROUND Recent agents, that is, pemetrexed and bevacizumab, have shown reproductive negative association between squamous histology. According to these agents' effectiveness, ruling out of the squamous histology is a significant issue for surgical pathologists. Several articles have proposed the distinction of peripheral type from central type of squamous cell carcinoma (SqCC) due to its sim...

Intestinal type of lung adenocarcinoma (ILADC) was initially described by Tsao and Fraser in 1991. Morphology and immunophenotype of ILADC are the same as in colorectal adenocarcinoma. Rectocolonoscopy must be performed to exclude colorectal origin of adenocarcinoma. Colorectal adenocarcinoma claimed to be genetically similar to an ILADC. Patients. We describe 24- and 26-year-old patients of bo...

Large cell carcinoma with or without neuroendocrine features (LCNEC and LC, respectively) constitutes 3-9% of non-small cell lung cancer but is poorly characterized at the molecular level. Herein we analyzed 41 LC and 32 LCNEC (including 15 previously reported cases) tumors using massive parallel sequencing for mutations in 26 cancer-related genes and gene fusions in ALK, RET, and ROS1. LC pati...

Squamous cell carcinoma (SCC) and premalignant endobronchial lesions have been difficult to study in murine models. In this study, we evaluate the topical N-nitroso-tris-chloroethylurea (NTCU) murine SCC model, determine the extent to which resulting premalignant airway dysplasia develops, discuss clinicopathologic grading criteria in lesion progression, and confirm that immunohistochemical (IH...

TOPIC: Lung Pathology TYPE: Fellow Case Reports INTRODUCTION: Pulmonary Sarcomatoid carcinomas (PSC) are rare, poorly-differentiated variants of Non-small cell lung cancers (NSCLC) that comprise 0.3-3% all primary neoplasms. Diagnosis PSC mainly relies on light microscopy while Immunohistochemical (IHC) panel lacks definitive role for diagnostic confirmation CASE PRESENTATION: A 60-year-old Afg...

While endometrial cancers are associated with favourable outcomes due to early symptomatic evaluation, patients high-risk features at a higher risk of recurrence. Although results PORTEC-3 trial established the role concurrent chemoradiation followed by adjuvant chemotherapy for cancer patients, its concordance data in South Asian populations is lacking. Present study aims assess toxicity profi...

TOPIC: Lung Cancer TYPE: Medical Student/Resident Case Reports INTRODUCTION: We report a unique case of lung cancer involving two different histologic variants. Mucoepidermoid carcinoma (MEC) salivary gland-type tumor and conventional adenocarcinoma CASE PRESENTATION: The patient in this study is 57-year-old male non-smoker with history hypertension, prostate deep venous thrombosis, who was inc...