The solubility of naproxen in binary mixtures of polyethylene glycol 200 (PEG 200) + water at the temperature range from 298.0 K to 318.0 K were reported. The combinations of Jouyban-Acree model + van't Hoff and Jouyban-Acree model + partial solubility parameters were used to predict the solubility of naproxen in PEG 200 + water mixtures at different temperatures. Combination of Jouyban-Acree m...

Participants Patients were eligible if they had received benefits from Ohio Medicaid or Michigan Medicaid and had received naproxen sodium or ibuprofen, but not both drugs. From a cohort of 378 919 patients in the Computerized On-Line Medical Pharmaceutical Analysis and Surveillance System (COMPASS), 59 patients (54% men) who were admitted to hospital for upper gastrointestinal tract bleeding w...

BACKGROUND The cardiovascular safety of celecoxib, as compared with nonselective nonsteroidal antiinflammatory drugs (NSAIDs), remains uncertain. METHODS Patients who required NSAIDs for osteoarthritis or rheumatoid arthritis and were at increased cardiovascular risk were randomly assigned to receive celecoxib, ibuprofen, or naproxen. The goal of the trial was to assess the noninferiority of ...

introduction: temporomandibular disorders (tmd) lead to masticatory muscle pain, jaw movement disability and limitation in mouth opening. pain is the chief complaint in 90% of the tmd patients which leads to disability and severe socioeconomic costs. the purpose of this study was to evaluate the therapeutic effects of low level laser therapy (lllt) compared to pharmacotherapy with nsaids (napro...

The aim of this study was to prepare w/o Micro-emulsions naproxen for topical application & evaluate in vitro permeation Naproxen. On the basis ternary phase diagram and drug solubility test Tween-20, Oleic acid Polyethylene Glycol 400 selected these are eminently used as an appropriate transporting system introducing Naproxen transdermal delivery. physicochemical properties microemulsions ...

The electrochemical response of S- and R-naproxen enantiomers was investigated on L-cysteine/reduced graphene oxide modified glassy carbon electrode (L-Cys/RGO/GCE). The production of the reduced graphene oxide and L-cysteine on the surface of the glassy carbon electrode was done by using electrochemical processes. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were us...

BACKGROUND This meta-analysis aimed to assess whether the specific nonsteroidal anti-inflammatory drug (NSAID) naproxen has a role in reducing the occurrence of heterotopic ossification after hip surgery. METHODS Potential studies were identified in the following electronic databases: PubMed, EMBASE, Web of Science, Cochrane Library, and Google. We included studies involving hip surgery patie...

Improving the solubility and changing the dissolution rate of the poorly soluble active pharmaceutical ingredients (API’s) AMG 517, glipizide, and naproxen through the preparation of eutectic mixtures was investigated. Mixtures of the API’s with other small molecules were prepared to construct a phase diagram used to identify the eutectic mixture compositions. The search for a eutectic mixture ...

Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen ...

BACKGROUND Non-steroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed agents for arthritic patients, although gastric effects limit their long-term use. Considering the reported gastric safety of hydrogen sulfide (H2S)-releasing NSAIDs, in addition to the anti-inflammatory effects of H2S administration to rats with synovitis, we decided to evaluate the effects of the H2S-rel...