نتایج جستجو برای: nano toxicity

تعداد نتایج: 167521  

Journal: : 2023

Extracts of Phaleria macrocarpa have been used for years in traditional medicine and evaluated scientifically as well. This study aimed to evaluate the chronic toxicity level nano herbal its effect on changes hematology, biochemistry, electrolytes, organ histopathology. High Energy Milling (HEM) produced . By giving at doses 300, 600, 900 mg/kg BW 56 days, mice’s blood was collected hematologic...

Journal: :Toxicology letters 2006
Zhen Chen Huan Meng Gengmei Xing Chunying Chen Yuliang Zhao Guang Jia Tiancheng Wang Hui Yuan Chang Ye Feng Zhao Zhifang Chai Chuanfeng Zhu Xiaohong Fang Baocheng Ma Lijun Wan

To assess the toxicity of copper nanoparticles (23.5 nm) in vivo, LD(50), morphological changes, pathological examinations and blood biochemical indexes of experimental mice are studied comparatively with micro-copper particles (17 microm) and cupric ions (CuCl(2).2H(2)O). The LD(50) for the nano-, micro-copper particles and cupric ions exposed to mice via oral gavage are 413, >5000 and 110 mg/...

2017
Leila Kanaani Meysam Ebrahimi Far S Maryam Kazemi Edris Choupani Maral Mazloumi Tabrizi Hasan Ebrahimi Shahmabadi Azim Akbarzadeh Khiyavi

The initial response to treatment and subsequent development of resistance to carboplatin are very important challenges. Use of nano drug delivery is a new method to replace standard chemotherapy. In this research, both non-PEGylated and PEGylated nanoparticles (NPs) were prepared by mini-emulsion polymerization of poly (butyl cyanoacrylate) (PBCA) NPs. Characteristics such as size, polydispers...

2009
Birgit K Gaiser Teresa F Fernandes Mark Jepson Jamie R Lead Charles R Tyler Vicki Stone

The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cel...

2016
Zhihang Chen Balaji Krishnamachary Zaver M. Bhujwalla

Although small interfering RNA (siRNA) therapy has proven to be a specific and effective treatment in cells, the delivery of siRNA is a challenge for the applications of siRNA therapy. We present a degradable dextran with amine groups as an siRNA nano-carrier. In our nano-carrier, the amine groups are conjugated to the dextran platform through the acetal bonds, which are acid sensitive. Therefo...

2012
Sara Novak Damjana Drobne Anja Menard

Nanoparticles of titanium dioxide are one of most widely used nanomaterials in different products in everyday use and in industry, but very little is known about their effects on non- target cells and tissues. Terrestrial isopods were exposed to food dosed with nano-TiO(2) to give final nominal concentration 1000 and 2000 µg TiO(2)/g dry weight of food. The effects of ingested nano-TiO(2) on th...

2016
Zorawar Singh

Graphene, a two dimensional (2D) planar and hexagonal array of carbon atoms, interacts with biological systems in different ways. Pristine graphene has been found to produce different responses as compared to its nano-composites. Graphene and its derivatives have been tested for their toxic effects on human erythrocytes, skin fibroblasts and different human cell lines including HepG2, A498, Cac...

2014
Devasier Bennet Se Chan Kang Jongback Gang Sanghyo Kim

Plants contain enriched bioactive molecules that can protect against skin diseases. Bioactive molecules become unstable and ineffective due to unfavorable conditions. In the present study, to improve the therapeutic efficacy of phytodrugs and enhance photoprotective capability, we used poly(D,L-lactide-co-glycolide) as a carrier of apple peel ethanolic extract (APETE) on permeation-enhanced nan...

ژورنال: کومش 2019
Dadmanesh , maryamMaryam , Dadpey , Masoumeh , Farahi , Kiavash, Ghorban , Khodayar ,

Introduction: Industrial and environmental pollution, excessive iron supplementation and blood transfusion are among the factors that may cause iron toxicity. Therefore, it is necessary to identify the mechanisms influencing or protecting against iron toxicity. The present study aimed to investigate the protective effects of quercetin as an antioxidant on hepatotoxicity induced by iron oxide an...

Journal: :Critical reviews in toxicology 2007
Gerhard J Nohynek Jürgen Lademann Christele Ribaud Michael S Roberts

Many modern cosmetic or sunscreen products contain nano-sized components. Nanoemulsions are transparent and have unique tactile and texture properties; nanocapsule, nanosome, noisome, or liposome formulations contain small vesicles (range: 50 to 5000 nm) consisting of traditional cosmetic materials that protect light-or oxygen-sensitive cosmetic ingredients. Transdermal delivery and cosmetic re...

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